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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of comorbid and demographic factors on dialysis modality choice and related patient survival in Europe
Nephrology Dialysis Transplantation, Volume 26, No. 9, Year 2011
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Description
Background. The mean age of patients starting dialysis increased over the years, as has the proportion of patients with diabetes mellitus, ischaemic heart disease, peripheral vascular disease (PVD), cerebrovascular disease (CD) and malignancy. We assessed dialysis modality choice within subgroups of patients with these comorbidities and in different age categories and subsequently evaluated the association between modality choice and patient survival in these subgroups.Methods. Seven European renal registries participating in the ERA-EDTA Registry provided data from 15828 incident peritoneal dialysis (PD) and haemodialysis (HD) patients (1998-2006) with available comorbidity data. The likelihood to receive PD rather than HD was assessed with logistic regression and 3-year survival on PD versus HD was evaluated using Cox regression.Results. Besides large international variations in the likelihood to receive PD, we found that elderly patients and patients with PVD, CD, malignancy and multiple comorbidities were significantly less likely to receive PD than HD. Overall patients starting on PD had survival benefits [adjusted hazard ratio (HRadj) 0.82 (0.75-0.90)], especially patients without comorbidity [HRadj 0.65 (0.53-0.80)] or those with malignancy [HRadj 0.73 (0.56-0.94)]. In males, survival benefits of PD were independent of diabetic status. Conversely, diabetic females tended to have increased mortality risk on PD [HRadj 1.16 (0.93-1.44)], especially if they were >70 years [HRadj 1.55 (1.15-2.08)].Conclusions. In general, modality choice was consistent with expected survival. However, elderly patients, non-diabetic patients and those with malignancy were less likely to receive PD, even though they had decreased mortality risk on PD. Also, although a survival benefit of PD was found for male patients without comorbidity, HD was just as likely to be the chosen dialysis modality as was PD for these patients. © The Author 2010. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Authors & Co-Authors
van de Luijtgaarden, Moniek W.M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Noordzij, Marlies
Netherlands, Amsterdam
Universiteit Van Amsterdam
Stel, Vianda S.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Ravani, Pietro
Canada, Calgary
Cumming School of Medicine
Jarraya, FaïÇal
Tunisia, Sfax
Chu Hedi-chaker
Collart, Frédéric E.
Belgium, Brussels
French-belgian Esrd Registry
Schön, Staffan
Sweden, Jonkoping
Swedish Renal Registry
Sweden, Lund
Medical Office
Leivestad, Torbjörn O.Rn
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Puttinger, Heidi
Austria, Vienna
Medizinische Universität Wien
Wanner, Christoph
Germany, Wurzburg
Universitätsklinikum Würzburg
Jager, Kitty J.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 102
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1093/ndt/gfq845
ISSN:
09310509
e-ISSN:
14602385
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Participants Gender
Male
Female