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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Invasive lobular carcinomas of the breast - The prognosis of histopathological subtypes
British Journal of Cancer, Volume 60, No. 4, Year 1989
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Description
One hundred and seventy-one cases of operable invasive lobular carcinoma, presenting over an 11-year period, were reviewed. Histological subtypes were investigated to determine differences in their clinical behaviour and whether these differences could be explained by histopathological features. Five subtypes were identified: mixed (45.6%), classical (30.4%), tubulo-lobular (13.5%), solid (6.4%) and alveolar (4.1%). The median follow-up period was 64 months and the median age 54 years. The 12-year actuarial survival rate was 100% for the tubulo-lobular subtype, but only 47% for the solid variant. Similar differences were found in the disease free interval, locoregional and distant metastatic rates between these two subtypes. The tubulo-lobular tumours were more likely to be of good histological grade and node negative. The other three subtypes did not differ significantly in their histopathological parameters, reflected in similar clinical behaviour. They occupied an intermediate position between the other two subtypes in terms of prognosis. © 1989 The Macmillan Press Ltd.
Authors & Co-Authors
Du Toit, R. S.
United Kingdom, Nottingham
Nottingham City Hospital
South Africa, Bloemfontein
Universitas Private Hospital
Locker, A. P.
United Kingdom, Nottingham
Nottingham City Hospital
Ellis, Ian O.
United Kingdom, Nottingham
Nottingham City Hospital
Elston, Christopher W.E.
United Kingdom, Nottingham
Nottingham City Hospital
Nicholson, Robert Ian
United Kingdom, Cardiff
Tenovus Inst. Cancer Res.
Blamey, Roger W.
United Kingdom, Nottingham
Nottingham City Hospital
Statistics
Citations: 95
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1038/bjc.1989.323
e-ISSN:
15321827
Research Areas
Cancer
Study Design
Cohort Study