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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats
Oxidative Medicine and Cellular Longevity, Article 434195, Year 2012
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Description
Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results, in a rat model of DOX-induced cardiotoxicity, show that DOX treatment significantly increased serum levels of LDH and CK-MB, indicators of cardiac injury, and induced expression of hypertrophic gene markers. DOX also caused marked decreases in the cardiac levels of glutathione, CoA-SH and ATP, and mRNA expression of catalase and NQO-1. These biochemical changes were associated with myocardial histopathological and ultrastructural deteriorations, as observed by light and electron microscopy, respectively. Cotreatment with MET (500mg/kg) eliminated all DOX-induced biochemical, histopathological, and ultrastructural changes. These findings demonstrate that MET successfully prevents DOX-induced cardiotoxicity in vivo by inhibiting DOX-induced oxidative stress, energy starvation, and depletion of intramitochondrial CoA-SH. © 2012 Abdelkader E. Ashour et al.
Authors & Co-Authors
Ashour, Abdelkader Elbadawy
Saudi Arabia, Riyadh
College of Pharmacy
Sayed-Ahmed, Mohamed M.
Saudi Arabia, Riyadh
College of Pharmacy
Abd-Allah, Adel Rashad A.
Saudi Arabia, Riyadh
College of Pharmacy
Korashy, Hesham Mohamed
Saudi Arabia, Riyadh
College of Pharmacy
Maayah, Zaid H.
Saudi Arabia, Riyadh
College of Pharmacy
Alkhalidi, Hisham Mohammed Said
Saudi Arabia, Riyadh
College of Medicine
Mubarak, Mohammed M.
Saudi Arabia, Riyadh
College of Medicine
Alhaider, Abdulqader A.
Saudi Arabia, Riyadh
College of Pharmacy
Statistics
Citations: 72
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1155/2012/434195
e-ISSN:
19420994
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Violence And Injury