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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of adenovirus vectors containing serotype 35 fibers for tumor targeting
Cancer Gene Therapy, Volume 13, No. 12, Year 2006
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Description
There is growing evidence from in vitro studies that subgroup B adenoviruses (Ad) can overcome the limitations in safety and tumor transduction efficiency seen with commonly used subgroup C serotype 5-based vectors. In this study, we confirm that the expression level of the B-group Ad receptor, CD46, correlates with the grade of malignancy of cervical cancer in situ. We also demonstrate the in vivo properties of Ad5-based vectors that contain the B-group Ad serotype 35 fiber (Ad5/35) in transgenic mice that express CD46 in a pattern and at a level similar to humans. Upon intravenous and intraperitoneal injection, an Ad5/35 vector did not efficiently transduce normal tissue, but was able to target metastatic or intraperitoneal tumors that express CD46 at levels comparable to human tumors. When an oncolytic Ad5/35-based vector was employed, in both tumor models antitumor effects were observed. Furthermore, injection of Ad5/35 vectors into CD46 transgenic mice caused less innate toxicity than Ad5 vectors. Our data demonstrate that Ad vectors that target CD46 offer advantages over Ad5-based vectors for treatment of cancer. © 2006 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Ni, Shaoheng
United States, Seattle
University of Washington
Gaggar, Anuj
United States, Seattle
University of Washington
Di Paolo, N.
United States, Seattle
University of Washington
Li, Zongyi
United States, Seattle
University of Washington
Liu, Y.
United States, Seattle
University of Washington
Strauss, Robert
United States, Seattle
University of Washington
Sova, Pavel
United States, Seattle
University of Washington
Morihara, J.
United States, Seattle
University of Washington
Feng, Quinghua
United States, Seattle
University of Washington
Kiviat, Nancy B.
United States, Seattle
University of Washington
Touré, Papa Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sow, Papa Salif
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Lieber, André
United States, Seattle
University of Washington
Statistics
Citations: 54
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1038/sj.cgt.7700981
ISSN:
09291903
Research Areas
Cancer