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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance
Molecular Cell, Volume 59, No. 1, Year 2015
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Description
Within bacterial populations, a small fraction of persister cells is transiently capable of surviving exposure to lethal doses of antibiotics. As a bet-hedging strategy, persistence levels are determined both by stochastic induction and by environmental stimuli called responsive diversification. Little is known about the mechanisms that link the low frequency of persisters to environmental signals. Our results support a central role for the conserved GTPase Obg in determining persistence in Escherichia coli in response tonutrient starvation. Obg-mediated persistence requires the stringent response alarmone (p)ppGpp and proceeds through transcriptional control of the hokB-sokB type I toxin-antitoxin module. In individual cells, increased Obg levels induce HokB expression, which in turn results in a collapse of the membrane potential, leading to dormancy. Obg also controls persistence in Pseudomonas aeruginosa and thus constitutes a conserved regulator of antibiotic tolerance. Combined, our findings signify an important step toward unraveling shared genetic mechanisms underlying persistence. © 2015 Elsevier Inc.
Authors & Co-Authors
Verstraeten, Natalie
Belgium, Leuven
Ku Leuven
Fierro, Ana Carolina
Belgium, Leuven
Ku Leuven
Marchal, Kathleen
Belgium, Leuven
Ku Leuven
Belgium, Ghent
Universiteit Gent
Beirlant, Jan
Belgium, Leuven
Ku Leuven
Hofkens, Johan
Belgium, Leuven
Ku Leuven
Fauvart, Maarten
Belgium, Leuven
Ku Leuven
Michiels, Jan
Belgium, Leuven
Ku Leuven
Statistics
Citations: 218
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.molcel.2015.05.011
ISSN:
10972765
Research Areas
Genetics And Genomics