Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children
AIDS, Volume 24, No. 8, Year 2010
Notification
URL copied to clipboard!
Description
Background: HIV-subtype D is associated with more rapid disease progression and higher rates of dementia in Ugandan adults compared with HIV-subtype A. There are no data comparing neuropsychological function by HIV subtype in Ugandan children. Design: One hundred and two HIV-infected antiretroviral therapy (ART) naive Ugandan children 6-12 years old (mean 8.9) completed the Kaufman Assessment Battery for Children, second edition (KABC-2), the Test of Variables of Attention (TOVA), and the Bruininks-Oseretsky Test for Motor Proficiency, second edition (BOT-2). Using a PCR-based multiregion assay with probe hybridization in five different regions (gag, pol, vpu, env, gp-41), HIV subtype was defined by hybridization in env and by total using two or more regions. Analysis of covariance was used for multivariate comparison. Results: The env subtype was determined in 54 (37 A, 16 D, 1 C) children. Subtype A and D groups were comparable by demographics, CD4 status, and WHO stage. Subtype A infections had higher log viral loads (median 5.0 vs. 4.6, P = 0.02). Children with A performed more poorly than those with D on all measures, especially on KABC-2 Sequential Processing (memory) (P = 0.01), Simultaneous Processing (visual-spatial analysis) (P = 0.005), Learning (P = 0.02), and TOVA visual attention (P = 0.04). When adjusted for viral load, Sequential and Simultaneous Processing remained significantly different. Results were similar comparing by total HIV subtype. Conclusion: HIV subtype A children demonstrated poorer neurocognitive performance than those with HIV subtype D. Subtype-specific neurocognitive deficits may reflect age-related differences in the neuropathogenesis of HIV. This may have important implications for when to initiate ART and the selection of drugs with greater central nervous system penetration. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Boivin, Michael Joseph
United States, East Lansing
Michigan State University
Ruel, Theodore D.
United States, San Francisco
University of California, San Francisco
Boal, Hannah E.
United States, Seattle
Seattle Children's Hospital
Bangirana, Paul
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Cao, Huyen L.
United States, Berkeley
Viral Rickettsial Disease Laboratory
Eller, Leigh Anne
Uganda, Kampala
Makerere University
Charlebois, Edwin D.
United States, San Francisco
Ucsf School of Medicine
Havlir, Diane V.
United States, San Francisco
University of California, San Francisco
Kamya, Moses Robert K.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Achan, Jane
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Akello, Caroline
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Wong, Joseph K.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 60
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1097/QAD.0b013e3283389dcc
e-ISSN:
14735571
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Mental Health