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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Iron, butnot folic acid, combined with effective antimalarial therapy promotes haematological recovery inAfrican children after acute falciparum malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 89, No. 6, Year 1995
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Description
Whether children with malarial anaemia should receive supplementation with iron or folic acid is uncertain. Therefore, the effects of supplementary treatment with iron or folic acid, given together with chloroquine or pyrimethamine-sulfadoxine (Fansidar®), has been assessed in 600 Gambian children with uncomplicated falciparum malaria. After one month, haematological recovery was significantly better in the group treated with Fansidar® than in the chloroquine-treated group (difference in mean haemoglobin level = 0.54 g/dL, P = 0.01). Children who received iron had a significantly better response than those given placebo(differences in mean haemoglobin level after onemonth and at dry season follow-up = 0.70 g/dL, P = 0.006, and 0.81 g/dL, P = 0.001, respectively). Iron supplementation was not associated with increased prevalence of malaria. Supplementation with folic acid did not improve the haematological response but, among children who received Fansidar®, the treatment failurerate was significantly higher among those given folic acid than among those given placebo. Thus, supplementation with iron, but not folic acid, improves haematological recovery without increasing susceptibility to malaria. © 1995 Oxford University Press.
Authors & Co-Authors
Boele van Hensbroek, Michael
Gambia, Banjul
Medical Research Council Laboratories Gambia
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Morris-Jones, Stephen D.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Meisner, Sarah J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jaffar, Shabbar S.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Bayo, Lang
Gambia, Banjul
Medical Research Council Laboratories Gambia
Dackour, Raduwan
Gambia, Banjul
Medical Research Council Laboratories Gambia
Phillips, Christine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 152
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/0035-9203(95)90438-7
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study