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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Universal detection and identification of avian influenza virus by use of resequencing microarrays
Journal of Clinical Microbiology, Volume 47, No. 4, Year 2009
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Description
Zoonotic microbes have historically been, and continue to emerge as, threats to human health. The recent outbreaks of highly pathogenic avian influenza virus in bird populations and the appearance of some human infections have increased the concern of a possible new influenza pandemic, which highlights the need for broad-spectrum detection methods for rapidly identifying the spread or outbreak of all variants of avian influenza virus. In this study, we demonstrate that high-density resequencing pathogen microarrays (RPM) can be such a tool. The results from 37 influenza virus isolates show that the RPM platform is an effective means for detecting and subtyping influenza virus, while simultaneously providing sequence information for strain resolution, pathogenicity, and drug resistance without additional analysis. This study establishes that the RPM platform is a broad-spectrum pathogen detection and surveillance tool for monitoring the circulation of prevalent influenza viruses in the poultry industry and in wild birds or incidental exposures and infections in humans. © 2009, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2668298/bin/supp_47_4_988__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2668298/bin/supp_47_4_988__Supplemental_materials.zip
Authors & Co-Authors
Lin, Baochuan
United States, Washington, D.c.
U.s. Naval Research Laboratory
Malanoski, Anthony Peter
United States, Washington, D.c.
U.s. Naval Research Laboratory
Wang, Zheng
United States, Washington, D.c.
U.s. Naval Research Laboratory
Blaney, Kate M.
United States, Alexandria
Nova Research, Inc.
Long, Nina C.
United States, Alexandria
Nova Research, Inc.
Meador, Carolyn E.
United States, Alexandria
Nova Research, Inc.
Metzgar, David
United States, San Diego
Naval Medical Center San Diego
Myers, Christopher A.
United States, San Diego
Naval Medical Center San Diego
Yingst, Samuel L.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Monteville, Marshall R.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Saad, Magdi Darwish
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Schnur, Joel M.
United States, Washington, D.c.
U.s. Naval Research Laboratory
United States, Fairfax
George Mason University
Tibbetts, Clark J.B.
United States, Sterling
Tessarae Llc
Stenger, David Andrew
United States, Washington, D.c.
U.s. Naval Research Laboratory
Statistics
Citations: 40
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1128/JCM.01346-08
ISSN:
00951137
Research Areas
Infectious Diseases