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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Recipient levels and function of von Willebrand factor prior to liver transplantation and its consumption in the course of grafting correlate with hepatocellular damage and outcome
Transplant International, Volume 18, No. 11, Year 2005
Notification
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Description
Von Willebrand factor (vWF) is a major platelet adhesion molecule at sites of vascular injury, such as observed in ischemia/reperfusion injury following orthotopic liver transplantation (OLT). Thirty-three OLT patients were divided into groups with elevated or low markers of hepatocellular damage (high and low-HD). Whole-blood aggregometry was performed to evaluate platelet function. Multimeric analysis was utilized to evaluate functional vWF levels in the course of OLT. Donor and recipient demographics were comparable among groups. Low-HD patients demonstrated better preserved coagulation parameters on POD 1-6 if contrasted to high-HD patients. One year graft survival for the high-HD group was lower than low-HD patients (P = 0.037). Preoperative vWF-dependent platelet aggregation and functional vWF plasma levels correlated directly with alanine transaminase levels early after OLT as did the decrease of functional vWF to reperfusion. In summary, these data suggest that vWF may serve as a significant mediator of platelet recruitment and hepatocellular injury in the graft following reperfusion. © 2005 European Society for Organ Transplantation.
Authors & Co-Authors
Schulte Am Esch, Jan
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Hösch, Stefan Benedikt
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Fischer, Lutz Ingo
Germany, Hamburg
Universität Hamburg
Knoefel, Wolfram Trudo
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Rogiers, Xavier C.
Germany, Hamburg
Universität Hamburg
Statistics
Citations: 15
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1432-2277.2005.00110.x
ISSN:
14322277
Research Areas
Violence And Injury