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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-1 mother-to-child transmission, post-test counselling, and antiretroviral prophylaxis in Northern Viet Nam: A prospective observational study
Scandinavian Journal of Infectious Diseases, Volume 44, No. 11, Year 2012
Notification
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Description
Background: Pregnant women fear being identified as HIV-1-infected and this has hampered prevention programmes and the calculation of transmission rates in Viet Nam. We introduced post-test counselling, antiretroviral prophylaxis, and formula feeding, and determined the vertical transmission rate in parts of Northern Viet Nam. Methods: HIV infection was identified in 234 pregnant women; 182 (77.8%) accepted follow-up of their children. Counselling was given on 37 occasions for altogether approximately 6 h on antiretroviral prophylaxis and formula feeding to avoid transmission, and on the importance of surveillance of the child. All children were formula-fed. A polymerase chain reaction (PCR) was used for the diagnosis of HIV-1 in the children. One hundred and thirty-five of the 182 mothers allowed ≥3 blood samples to be taken from birth to ≥1 y of age, 32/182 provided a birth sample only, and 15/182 provided a sample later only. Nevirapine was given at delivery to 93/135 (69%) women, and to 128/135 (95%) children. Additionally, combination therapy was given to 15/135 (11%) who entered the study before delivery, and azidothymidine to their children for 1 week. Results: Nine of 135 (6.7%) children became infected and 2/15 of the others, giving altogether 11/150 infected (7.3%). Intrauterine transmission was identified in 7/167 (4.2%) children by a positive PCR test at birth. PCR was negative at birth but positive at 1 month in 2/135 (1.5%), pointing to delivery-associated transmission. Thus, intrauterine transmission accounted for 78% (7/9). None of the uninfected children died, but 3/11 (p 0.004) of the HIV-1-infected died (in AIDS). Conclusion: Post-test confidential counselling, formula feeding, and antiretroviral prophylaxis resulted in low rates of delivery-associated and late HIV-1 transmissions. © 2012 Informa Healthcare.
Authors & Co-Authors
Ha, Tran Thi Thanh
Sweden, Stockholm
Karolinska Institutet
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
United States, Durham
Fhi 360
Anh, Nguyen Mai
Viet Nam
Haiphong Obstetric and Gynaecology Hospital
Bao, Nguyen Huy
Viet Nam, Hanoi
National Hospital of Obstetrics and Gynaecology
Tuan, Pham L.
Viet Nam, Hanoi
Ministry of Health Vitenam
Caridha, Rozina
Sweden, Stockholm
Karolinska Institutet
Gaseitsiwe, Simani
Sweden, Stockholm
Karolinska Institutet
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Hien, Nguyen Tran
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Cam, Phung Dac
Viet Nam, Hanoi
National Institute of Hygiene and Epidemiology Hanoi
Ehrnst, Anneka C.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 9
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.3109/00365548.2012.690160
ISSN:
00365548
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Female