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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire
PLoS Neglected Tropical Diseases, Volume 5, No. 11, Article e1384, Year 2011
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Description
Background: Promising results have been reported for a urine circulating cathodic antigen (CCA) test for the diagnosis of Schistosoma mansoni. We assessed the accuracy of a commercially available CCA cassette test (designated CCA-A) and an experimental formulation (CCA-B) for S. mansoni diagnosis. Methodology: We conducted a cross-sectional survey in three settings of Côte d'Ivoire: settings A and B are endemic for S. mansoni, whereas S. haematobium co-exists in setting C. Overall, 446 children, aged 8-12 years, submitted multiple stool and urine samples. For S. mansoni diagnosis, stool samples were examined with triplicate Kato-Katz, whereas urine samples were tested with CCA-A. The first stool and urine samples were additionally subjected to an ether-concentration technique and CCA-B, respectively. Urine samples were examined for S. haematobium using a filtration method, and for microhematuria using Hemastix dipsticks. Principal Findings: Considering nine Kato-Katz as diagnostic 'gold' standard, the prevalence of S. mansoni in setting A, B and C was 32.9%, 53.1% and 91.8%, respectively. The sensitivity of triplicate Kato-Katz from the first stool and a single CCA-A test was 47.9% and 56.3% (setting A), 73.9% and 69.6% (setting B), and 94.2% and 89.6% (setting C). The respective sensitivity of a single CCA-B was 10.4%, 29.9% and 75.0%. The ether-concentration technique showed a low sensitivity for S. mansoni diagnosis (8.3-41.0%). The specificity of CCA-A was moderate (76.9-84.2%); CCA-B was high (96.7-100%). The likelihood of a CCA-A color reaction increased with higher S. mansoni fecal egg counts (odds ratio: 1.07, p<0.001). A concurrent S. haematobium infection or the presence of microhematuria did not influence the CCA-A test results for S. mansoni diagnosis. Conclusion/Significance: CCA-A showed similar sensitivity than triplicate Kato-Katz for S. mansoni diagnosis with no cross-reactivity to S. haematobium and microhematuria. The low sensitivity of CCA-B in our study area precludes its use for S. mansoni diagnosis. © 2011 Coulibaly et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3222626/bin/pntd.0001384.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3222626/bin/pntd.0001384.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3222626/bin/pntd.0001384.s003.doc
Authors & Co-Authors
Coulibaly, Jean Tenena
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
Knopp, Stefanie
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
N'Guéssan, Nicaise A.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Silué, Kigbafori Dieudonné
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
Fürst, Thomas
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Lohourignon, Laurent K.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Brou, Jean K.
Cote D'ivoire, Abidjan
C.h.u. de Cocody
N'Gbesso, Yves K.
Cote D'ivoire
Centre de Santé Rural D'azaguié
Vounatsou, P.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
N'Goran, Eliézer Kouakou
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Centre Suisse de Recherches Scientifiques Abidjan
Utzinger, Jürg
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Statistics
Citations: 131
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pntd.0001384
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Ivory Coast