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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Lebectin and lebecetin, two C-type lectins from snake venom, inhibit α5β1 and αv-containing integrins
Matrix Biology, Volume 26, No. 4, Year 2007
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Description
Integrins are essential protagonists in the complex multistep process of cancer progression and metastasis. We recently reported that lebectin, a novel C-type lectin from Macrovipera lebetina venom, displays an anti-integrin activity. In this study, we extend this observation to lebecetin, a second C-type lectin isolated from the same venom and previously reported as a potent inhibitor of platelet aggregation. Both venom lectins appear to exert their effect on cell adhesion, migration, invasion and proliferation by inhibiting α5β1 and αv-containing integrins. Moreover, the inhibition of α5β1 and αv integrins is likely due to the binding of venom peptides, as both lebectin and lebecetin co-immunoprecipitate with these integrins. Lebectin and lebecetin are thus the first examples of venom C-type lectins inhibiting an integrin other than the collagen receptor α2β1. © 2007 Elsevier B.V./International Society of Matrix Biology.
Authors & Co-Authors
Sarray, Sameh
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Delamarre, Estelle
France, Marseille
Aix Marseille Université
Marvaldi, Jacques L.
France, Marseille
Aix Marseille Université
El-Ayeb, Mohamed E.
Tunisia, Tunis
Institut Pasteur de Tunis
Marrakchi, Naziha
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Faculté de Médecine de Tunis
Luis, José
France, Marseille
Aix Marseille Université
Statistics
Citations: 56
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.matbio.2007.01.001
ISSN:
0945053X
Research Areas
Cancer