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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Increased cardiovascular risk in South African patients with addison's disease
Hormone and Metabolic Research, Volume 45, No. 12, Year 2013
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Description
Patients with Addison's disease (AD) are believed to be at risk for cardiovascular disease (CVD). South Africa, like the rest of the developing world is experiencing an increase in CVD and patients with AD may be at double the risk of their peers. We wished to explore AD patients' CVD risk factors. A cross-sectional nationwide study in South Africa of patients with AD was conducted. A cohort of 147 patients with AD and 147 healthy control subjects were matched by age, gender, ethnicity, and BMI as far as was possible. Lipoproteins and highly-sensitive C-reactive-protein (hs-CRP) were the main outcome measures. AD patients had significantly higher triglycerides; (p=0.001), lower HDLC (p<0.001), higher hs-CRP (p<0.001), and more small dense LDL; (p=0.002) than controls. Nonesterified fatty acids were lower in patients (p<0.001). Approximately 65% [95% confidence interval (CI 55.6-72.4%)] had hypercholesterolaemia, 75% (CI 64.8-81.2%) had low HDLC, and 75% (CI 68.0-84.1%) had a higher LDLC. Thirteen percent of AD patients had diabetes mellitus, but none of the risk factors differed from the nondiabetics. Only HDLC correlated positively with daily hydrocortisone dose (r=0.32; p=0.005). In conclusion dyslipidaemia is common in South African AD patients; CVD risk assessment and intervention are probably warranted in the management of these patients. © Georg Thieme Verlag KG Stuttgart, New York.
Authors & Co-Authors
Ross, Ian Louis
South Africa, Cape Town
University of Cape Town
Bergthorsdottir, Ragnhildur
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Levitt, Naomi S.
South Africa, Cape Town
University of Cape Town
Schatz, Desmond A.
United States, Gainesville
University of Florida
Johannsson, Gudmundur F.
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Marais, Adrian David
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 30
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1055/s-0033-1351259
ISSN:
00185043
e-ISSN:
14394286
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
South Africa