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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Geographic and breed distribution patterns of an A/G polymorphism present in the Mx gene suggests balanced selection in village chickens
International Journal of Poultry Science, Volume 9, No. 1, Year 2010
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Description
An A/G Single Nucleotide Polymorphism (SNP) at position 1,892 of the Mx gene coding sequence has been linked to susceptibility/resistance to avian viral infection in vitro. Using PCR-RFLP and sequencing methods, 1,946 samples from 109 populations from Asia, Africa and Europe; grouped as indigenous village, commercial, fancy chicken as well as wild junglefowl were genotyped for the polymorphism. Allele and genotype frequencies were calculated. Only the G allele was present in Ceylon junglefowl Gallus lafayetti. Using the wild red junglefowl G. gallus population as reference, we assessed if the A/G alleles and genotypes frequencies have been affected by the breeding history and the geographic dispersion of domestic chicken. Within group variation was high but overall there were no significant variation in distribution of alleles and genotypes frequencies between the red junglefowl and indigenous village chickens (p>0.1946), with the exception of the East Asian group (p<0.0001). However, allele and genotype frequencies were significantly different between the red junglefowl and the commercial or fancy groups (p<0.0001). A small but significant negative correlation (r = - 0.166, p<0.0003) was observed between allelic and geographic distance matrices amongst indigenous village chicken populations. Human selection and genetic drift are likely the main factors having shaped today's observed allele and genotype frequencies in commercial and fancy breeds. In indigenous village chicken and red junglefowl, we propose that both A and G alleles have been maintained by natural selection for disease resistance through a balancing selection mechanism. © Asian Network for Scientific Information, 2010.
Authors & Co-Authors
Ommeh, Sheila Cecily
Kenya, Nairobi
International Livestock Research Institute Nairobi
Jin, L. N.
Taiwan, Lanzhou
Gansu Agricultural University
China, Beijing
Chinese Academy of Agricultural Sciences
Eding, Herwin
Germany, Tubingen
Friedrich-loeffler-institute
Muchadeyi, Farai Catherine
Germany, Tubingen
Friedrich-loeffler-institute
Sulandari, S.
Indonesia, Central Jakarta
Lembaga Ilmu Pengetahuan Indonesia
Zein, Sima
Indonesia, Central Jakarta
Lembaga Ilmu Pengetahuan Indonesia
Danbaro, G.
Papua new Guinea, Lae
Papua new Guinea University of Technology
Wani, C. E.
Sudan, Khartoum
Ubg
Zhao, S. G.
Taiwan, Lanzhou
Gansu Agricultural University
China, Beijing
Chinese Academy of Agricultural Sciences
Nie, Qinghua
China, Guangzhou
South China Agricultural University
Zhang, Xiquan
China, Guangzhou
South China Agricultural University
Ndila, M.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Preisinger, R.
Germany, Cuxhaven
Lohmann Tierzucht Gmbh
Chen, G. H.
China, Yangzhou
Yangzhou University
Yousif, Ibrahim A.S.
Sudan, Khartoum
Khartoum University
Heo, K. N.
South Korea, Jeonju
Rural Development Administration
Oh, S. J.
Kenya, Nairobi
International Livestock Research Institute Nairobi
South Korea, Jeonju
Rural Development Administration
Tapio, Miika
Kenya, Nairobi
International Livestock Research Institute Nairobi
Masiga, Daniel K.
Kenya, Nairobi
International Centre of Insect Physiology and Ecology Nairobi
Hanotte, Olivier H.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United Kingdom, Nottingham
University of Nottingham
Jianlin, Han
Kenya, Nairobi
International Livestock Research Institute Nairobi
China, Beijing
Chinese Academy of Agricultural Sciences
Weigend, Steffen
Germany, Tubingen
Friedrich-loeffler-institute
Statistics
Citations: 22
Authors: 22
Affiliations: 14
Identifiers
Doi:
10.3923/ijps.2010.32.38
ISSN:
16828356
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study