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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids
Phytochemistry, Volume 68, No. 7, Year 2007
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Description
The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
McNulty, James
Canada, Hamilton
Mcmaster University
Nair, Jerald James
Canada, Hamilton
Mcmaster University
Codina Jané, C.
Spain, Barcelona
Universitat de Barcelona
Bastida, J.
Spain, Barcelona
Universitat de Barcelona
Statistics
Citations: 102
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.phytochem.2007.01.006
ISSN:
00319422
Research Areas
Cancer