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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Complete Khoisan and Bantu genomes from southern Africa
Nature, Volume 463, No. 7283, Year 2010
Notification
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Description
The genetic structure of the indigenous hunter-gatherer peoples of southern Africa, the oldest known lineage of modern human, is important for understanding human diversity. Studies based on mitochondrial and small sets of nuclear markers have shown that these hunter-gatherers, known as Khoisan, San, or Bushmen, are genetically divergent from other humans. However, until now, fully sequenced human genomes have been limited to recently diverged populations. Here we present the complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and a Bantu from southern Africa, as well as protein-coding regions from an additional three hunter-gatherers from disparate regions of the Kalahari. We characterize the extent of whole-genome and exome diversity among the five men, reporting 1.3 million novel DNA differences genome-wide, including 13,146 novel amino acid variants. In terms of nucleotide substitutions, the Bushmen seem to be, on average, more different from each other than, for example, a European and an Asian. Observed genomic differences between the hunter-gatherers and others may help to pinpoint genetic adaptations to an agricultural lifestyle. Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data. © 2010 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Schuster, Stephan C.
United States, University Park
Pennsylvania State University
Miller, Webb C.
United States, University Park
Pennsylvania State University
Ratan, Aakrosh
United States, University Park
Pennsylvania State University
Tomsho, Lynn P.
United States, University Park
Pennsylvania State University
Giardine, Belinda M.
United States, University Park
Pennsylvania State University
Kasson, Lindsay R.
United States, University Park
Pennsylvania State University
Harris, Robert S.
United States, University Park
Pennsylvania State University
Petersen, Desiree C.
Australia, Sydney
Unsw Sydney
Zhao, Fangqing
United States, University Park
Pennsylvania State University
Qi, Ji
United States, University Park
Pennsylvania State University
Alkan, Can
United States, Seattle
University of Washington
Kidd, Jeffrey M.
United States, Seattle
University of Washington
Sun, Yazhou
United States, University Park
Pennsylvania State University
Drautz, Daniela I.
United States, University Park
Pennsylvania State University
Bouffard, Pascal
United States, Indianapolis
Roche Diagnostics Corporation
Muzny, Donna Marie
United States, Houston
Baylor College of Medicine
Reid, Jeffrey G.
United States, Houston
Baylor College of Medicine
Nazareth, Lynne V.
United States, Houston
Baylor College of Medicine
Wang, Qingyu
United States, University Park
Pennsylvania State University
Burhans, Richard
United States, University Park
Pennsylvania State University
Riemer, Cathy
United States, University Park
Pennsylvania State University
Wittekindt, Nicola E.
United States, University Park
Pennsylvania State University
Moorjani, Priya G.
United States, Boston
Harvard Medical School
Tindall, Elizabeth A.
Australia, Sydney
Unsw Sydney
Danko, Charles G.
United States, Ithaca
Cornell University
Teo, Wee Siang
Australia, Sydney
Unsw Sydney
Buboltz, Anne M.
United States, University Park
Pennsylvania State University
Zhang, Zhenhai
United States, University Park
Pennsylvania State University
Ma, Qianyi
United States, University Park
Pennsylvania State University
Oosthuysen, A. W.
Unknown Affiliation
Steenkamp, Abraham W.
Unknown Affiliation
Oostuisen, Hermann
Unknown Affiliation
Venter, Philippus
Unknown Affiliation
Gajewski, John
South Africa, Sovenga
University of Limpopo
Zhang, Yu
United States, University Park
Pennsylvania State University
Pugh, B. Franklin
United States, University Park
Pennsylvania State University
Makova, Kateryna D.
United States, University Park
Pennsylvania State University
Nekrutenko, Anton
United States, University Park
Pennsylvania State University
Mardis, Elaine R.
United States, St. Louis
Washington University in St. Louis
Patterson, Nick J.
United States, Cambridge
Harvard University
Pringle, Thomas H.
United States, Eugene
Sperling Foundation
Chiaromonte, Francesca
United States, University Park
Pennsylvania State University
Mullikin, James C.
United States, Bethesda
National Human Genome Research Institute Nhgri
Eichler, Evan E.
United States, Seattle
University of Washington
Hardison, Ross C.
United States, University Park
Pennsylvania State University
Gibbs, Richard A.L.
United States, Houston
Baylor College of Medicine
Harkins, Timothy T.
United States, Indianapolis
Roche Diagnostics Corporation
Hayes, Vanessa M.
Australia, Sydney
Unsw Sydney
Statistics
Citations: 455
Authors: 48
Affiliations: 12
Identifiers
Doi:
10.1038/nature08795
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Male