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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study
Clinical Infectious Diseases, Volume 72, No. 8, Year 2021
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Description
Background: Aspergillus spp. of section Usti (A. ustus) represent a rare cause of invasive aspergillosis (IA). This multicenter study describes the epidemiology and outcome of A. ustus infections. Methods: Patients with A. ustus isolated from any clinical specimen were retrospectively identified in 22 hospitals from 8 countries. When available, isolates were sent for species identification (BenA/CaM sequencing) and antifungal susceptibility testing. Additional cases were identified by review of the literature. Cases were classified as proven/probable IA or no infection, according to standard international criteria. Results: Clinical report forms were obtained for 90 patients, of whom 27 had proven/probable IA. An additional 45 cases were identified from literature review for a total of 72 cases of proven/probable IA. Hematopoietic cell and solid-organ transplant recipients accounted for 47% and 33% cases, respectively. Only 8% patients were neutropenic at time of diagnosis. Ongoing antimold prophylaxis was present in 47% of cases. Pulmonary IA represented 67% of cases. Primary or secondary extrapulmonary sites of infection were observed in 46% of cases, with skin being affected in 28% of cases. Multiple antifungal drugs were used (consecutively or in combination) in 67% of cases. The 24-week mortality rate was 58%. A. calidoustus was the most frequent causal agent. Minimal inhibitory concentrations encompassing 90% isolates (MIC90) were 1, 8, >16, and 4 µg/mL for amphotericin B, voriconazole, posaconazole, and isavuconazole, respectively. Conclusions: Aspergillus ustus IA mainly occurred in nonneutropenic transplant patients and was frequently associated with extrapulmonary sites of infection. Mortality rate was high and optimal antifungal therapy remains to be defined. © 2020
Authors & Co-Authors
Cassaing, Sophie
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Fekkar, Arnaud
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Dannaoui, Eric
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Bougnoux, Marie Élisabeth
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Bretagne, Stéphane
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Neofytos, DIonysios
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Hennequin, Christophe
France, Paris
Centre de Recherche Saint-antoine
Morio, Florent
France, Nantes
Chu de Nantes
Bongomin, Felix A.
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Fernández-Ruiz, Mario
Spain, Madrid
Hospital Universitario 12 de Octubre
Bellanger, Anne Pauline
France, Besancon
Centre Hospitalier Universitaire de Besançon
Arikan-Akdagli, Sevtap
Turkey, Ankara
Hacettepe Üniversitesi
Khanna, Nina
Switzerland, Basel
Universitätsspital Basel
Brun, Sophie
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Gabriel, Frédéric
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Zbinden, Reinhard
Switzerland, Zurich
Universität Zürich
Le Pape, Patrice
France, Nantes
Chu de Nantes
Klimko, Nicholai Nikolaevich
Russian Federation, Saint Petersburg
North-western State Medical University Named After I.i. Mechnikov
Richardson, Malcolm D.
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Inkaya, Ahmet Çaǧkan
Turkey, Ankara
Hacettepe Üniversitesi
Coste, Alix T.
Switzerland, Lausanne
Université de Lausanne Unil
Bochud, Pierre Yves
Switzerland, Lausanne
Université de Lausanne Unil
Lamoth, Fréd́eric
Switzerland, Lausanne
Université de Lausanne Unil
Statistics
Citations: 22
Authors: 23
Affiliations: 20
Identifiers
Doi:
10.1093/cid/ciaa230
ISSN:
10584838
Study Design
Cohort Study
Study Approach
Systematic review