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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa
Nature Genetics, Volume 44, No. 11, Year 2012
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Description
A highly invasive form of non-typhoidal Salmonella (iNTS) disease has recently been documented in many countries in sub-Saharan Africa. The most common Salmonella enterica serovar causing this disease is Typhimurium (Salmonella Typhimurium). We applied whole-genome sequence-based phylogenetic methods to define the population structure of sub-Saharan African invasive Salmonella Typhimurium isolates and compared these to global Salmonella Typhimurium populations. Notably, the vast majority of sub-Saharan invasive Salmonella Typhimurium isolates fell within two closely related, highly clustered phylogenetic lineages that we estimate emerged independently ∼52 and ∼35 years ago in close temporal association with the current HIV pandemic. Clonal replacement of isolates from lineage I by those from lineage II was potentially influenced by the use of chloramphenicol for the treatment of iNTS disease. Our analysis suggests that iNTS disease is in part an epidemic in sub-Saharan Africa caused by highly related Salmonella Typhimurium lineages that may have occupied new niches associated with a compromised human population and antibiotic treatment. © 2012 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Okoro, Chinyere K.
United Kingdom, Hinxton
Wellcome Sanger Institute
Kingsley, Robert A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Connor, Thomas R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Harris, Simon R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Parry, Christopher Mark
Thailand, Nakhon Pathom
Mahidol University
United Kingdom, Liverpool
University of Liverpool
Al-Mashhadani, Manar N.
United Kingdom, Liverpool
University of Liverpool
Kariuki, Samuel M.
Kenya, Nairobi
Kenya Medical Research Institute
Msefula, Chisomo L.
Malawi, Zomba
University of Malawi
Gordon, Melita A.
United Kingdom, Liverpool
University of Liverpool
de Pinna, Elizabeth M.
United Kingdom, London
Public Health England
Wain, John R.
United Kingdom, London
Public Health England
United Kingdom, Norwich
University of East Anglia, Norwich Medical School
Heyderman, Robert Simon
Malawi, Zomba
University of Malawi
United Kingdom, Bristol
University of Bristol
Obaro, Stephen K.
United States, East Lansing
Michigan State University
Nigeria, Abuja
National Hospital, Abuja
Alonso, Pedro Luís
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mandomando, Inácio M.
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Mozambique, Maputo
Instituto Nacional de Saude Maputo
MacLennan, Calman Alexander
Italy, Siena
Novartis Vaccines and Diagnostic S.r.l.
United Kingdom, Birmingham
University of Birmingham
Tapia, Milagritos D.
United States, Baltimore
University of Maryland, Baltimore Umb
Levine, Myron M.
United States, Baltimore
University of Maryland, Baltimore Umb
Tennant, Sharon M.
United States, Baltimore
University of Maryland, Baltimore Umb
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
Dougan, Gordon J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 201
Authors: 21
Affiliations: 16
Identifiers
Doi:
10.1038/ng.2423
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study