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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pregnancy following liver transplantation during childhood and adolescence
Pediatric Transplantation, Volume 15, No. 7, Year 2011
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Description
More than 80% of pediatric transplant recipients will survive to reach adulthood, and many will consider having children. We report on outcomes and management of five pregnancies in four women undergoing orthotopic liver transplantation during childhood or adolescence and followed up at our Transplant Center. A retrospective clinical folder audit was performed. Mean age at transplantation was 13.3 ± 3.4 yr (range, 10-18 yr). Mean interval between transplantation and pregnancy was 15.4 ± 4.9 yr (range, 10-22 yr). Mean maternal age at conception was 28 ± 3.5 yr (range, 23-32 yr). Mean gestational age was 36.6 ± 1.7 wk. Mean birth weight was 2672 ± 249 g. Immunosuppression was cyclosporin based in three women and tacrolimus based in one woman. Pregnancy complications necessitating the induction of labor included fetal distress and rising maternal liver enzymes in two women, cholestasis of pregnancy and impaired renal graft function in one woman, fetal distress and preeclampsia in one woman. Modes of delivery were normal vaginal delivery in three women and cesarean section in one woman. No maternal or fetal deaths and no congenital malformations occurred. No episodes of rejection occurred during pregnancy. Two women experienced acute cellular rejection requiring an increase in baseline immunosuppression in the first year, following delivery. No graft losses occurred during a mean follow-up of 44 ± 17.9 months post-delivery. With careful management, pregnancy post-liver transplantation can have a successful outcome. © 2011 John Wiley & Sons A/S.
Authors & Co-Authors
Spearman, W. C.
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
Goddard, Elizabeth Anne
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
McCulloch, Mignon I.
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Hairwadzi, H. N.
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
Sonderup, Mark Wayne
South Africa, Observatory
Groote Schuur Hospital
South Africa, Cape Town
University of Cape Town
Kahn, Delawir H.
South Africa, Observatory
Groote Schuur Hospital
South Africa, Pretoria
The Surgery
Millar, Allistair John Ward
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 13
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1111/j.1399-3046.2011.01554.x
ISSN:
13973142
e-ISSN:
13993046
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female