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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Communications Biology, Volume 3, No. 1, Article 56, Year 2020
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Description
Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis. © 2020, The Author(s).
Authors & Co-Authors
Abascal, Federico
United Kingdom, Hinxton
Wellcome Sanger Institute
Bader, Gary D.
Canada, Toronto
University of Toronto
Beroukhim, Rameen
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Boroevich, Keith Anthony
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Brunak, Søren B.
Denmark, Lyngby
Technical University of Denmark
Denmark, Copenhagen
Københavns Universitet
Campbell, Peter J.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
University of Cambridge
Fonseca, Nuno A.
Portugal, Porto
Universidade do Porto
United Kingdom, Hinxton
European Molecular Biology Laboratory
Gambacorti Passerini, Carlo B.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Gerstein, Mark B.
United States, Princeton
Princeton University
United States, New Haven
Yale University
Getz, Gad A.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Gut, I. Glynne
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Harmanci, Arif Ozgun
United States, New Haven
Yale University
United States, Houston
University of Texas Health Science Center at Houston
Helmy, Mohamed
Canada, Toronto
University of Toronto
Hobolth, Asger
Denmark, Aarhus
Aarhus Universitet
Kahles, André
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Kellis, Manolis
United States, Cambridge
Massachusetts Institute of Technology
Kim, Jaegil
United States, Cambridge
Massachusetts Institute of Technology
Komorowski, Jan
Sweden, Solna
Science for Life Laboratory
Poland, Warszawa
Polish Academy of Sciences
Korbel, Jan O.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Lawrence, Michael S.
United States, Cambridge
Massachusetts Institute of Technology
Japan, Yokohama
Riken Center for Integrative Medical Sciences
United States, Boston
Massachusetts General Hospital
Lehmann, Kjong Van
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Marchal, Kathleen
Belgium, Ghent
Universiteit Gent
Martincorena, Iñigo
United Kingdom, Hinxton
Wellcome Sanger Institute
Meyerson, William U.
United States, New Haven
Yale University
Nakagawa, Hidewaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Pulido-Tamayo, Sergio
Belgium, Ghent
Universiteit Gent
Saksena, Gordon
United States, Cambridge
Massachusetts Institute of Technology
Schumacher, Steven E.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Shackleton, Mark J.
Australia, Melbourne
University of Melbourne
Shapira, Ofer
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Tiao, Grace
United States, Cambridge
Massachusetts Institute of Technology
Tsunoda, Tatsuhiko
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Kawaguchi
Japan Science and Technology Agency
Japan, Tokyo
Tokyo Medical and Dental University
Japan, Tokyo
Graduate School of Medicine
Valencia, Alfonso
Spain, Barcelona
Centro Nacional de Supercomputación
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Verbeke, Lieven P.C.
Belgium, Ghent
Universiteit Gent
Warrell, Jonathan H.
United States, New Haven
Yale University
Waszak, Sebastian M.
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Wheeler, David A.
United States, Houston
Baylor College of Medicine
Yu, Jun
Hong Kong, Hong Kong
Chinese University of Hong Kong
China, Shanghai
Second Military Medical University
Zhao, Zhongming Ming
United States, Houston
University of Texas Health Science Center at Houston
Statistics
Citations: 120
Authors: 39
Affiliations: 74
Identifiers
Doi:
10.1038/s42003-019-0741-7
ISSN:
23993642
Research Areas
Cancer
Genetics And Genomics