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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Analgesic and antiinflammatory activities of the ethyl acetate fraction of Bidens pilosa (Asteraceae)
Inflammopharmacology, Volume 22, No. 2, Year 2014
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Description
Bidens pilosa is an Asteraceae widely used in traditional medicine for the treatment of various ailments including pain and inflammation. The present work was undertaken to assess the analgesic and antiinflammatory properties of the ethyl acetate fraction of methylene chloride/methanol (1:1) extract of leaves of Bidens pilosa at the gradual doses of 50, 100 and 200 mg/kg in mice and rats, respectively. The analgesic properties of Bidens pilosa were investigated using the acetic acid writhing, hot plate, capsaicin and formalin-induced pain models. This was followed by a study of the antiinflammatory properties using carrageenan, dextran, histamine and serotonin to induce acute inflammation in rat hind paw. The extract provided a significant (p < 0.01) reduction in pain induced by all four models of nociception. It also presented significant (p < 0.05) antiinflammatory activity in all four models of acute inflammation. These results show that the ethyl acetate fraction of methylene chloride/methanol (1:1) of Bidens pilosa has both analgesic and antiinflammatory properties. The qualitative analysis of the fraction by the high-performance liquid chromatography (HPLC) fingerprint revealed the presence of two flavonoids, namely quercetin and iso-okanin, known to have antiinflammatory and antinociceptive properties, which could be responsible for the analgesic and antiinflammatory effects observed. © 2013 Springer.
Authors & Co-Authors
Fotso Fotso, Aurélien
Cameroon, Yaounde
Université de Yaoundé I
Longo, Frida
Cameroon, Yaounde
Université de Yaoundé I
Djomeni, Paul Désiré Dzeufiet
Cameroon, Yaounde
Université de Yaoundé I
Fogue Kouam, Siméon Fogué
Cameroon, Yaounde
Université de Yaoundé I
Spiteller, Michael
Germany, Dortmund
Technische Universität Dortmund
Dongmo, Alain Bertrand
Cameroon, Douala
University of Douala
Savineau, JP
France, Pessac
Centre de Recherche Cardio-thoracique de Bordeaux
Statistics
Citations: 29
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s10787-013-0196-2
ISSN:
09254692
e-ISSN:
15685608
Research Areas
Health System And Policy
Study Approach
Qualitative