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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The neoplastically transformed (CD30hi) Marek's disease lymphoma cell phenotype most closely resembles T-regulatory cells
Cancer Immunology, Immunotherapy, Volume 57, No. 8, Year 2008
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Description
Introduction: Marek's disease (MD), a herpesvirus-induced lymphoma of chickens is a unique natural model of CD30-overexpressing (CD30hi) lymphoma. We have previously proposed that the CD30hi neoplastically transformed CD4+ T cells in MD lymphomas have a phenotype antagonistic to cell mediated immunity. Here were test the hypothesis that the CD30hi neoplastically transformed MD lymphoma cells have a phenotype more closely resembling T-helper (Th)-2 or regulatory T (T-reg) cells. Materials and methods: We separated ex vivo-derived CD30hi, from the CD30lo/- (non-transformed), MD lymphoma cells and then quantified the relative amounts of mRNA and proteins for cytokines and other genes that define CD4+ Th-1, Th-2 or T-reg phenotypes. Results and discussion: Gene Ontology-based modeling of our data shows that the CD30hi MD lymphoma cells having a phenotype more similar to T-reg. Sequences that could be bound by the MD virus putative oncoprotein Meq in each of these genes' promoters suggests that the MD herpesvirus may play a direct role in maintaining this T-reg-like phenotype. © 2008 Springer-Verlag.
Authors & Co-Authors
Buza, Joram J.
United States, Mississippi State
Mississippi State University
Burgess, Shane C.
United States, Mississippi State
Mississippi State University
United States, Mississippi State
Mississippi Agricultural and Forestry Experiment Station
Statistics
Citations: 43
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1007/s00262-008-0460-2
ISSN:
03407004
Research Areas
Genetics And Genomics