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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of HLA alleles with Plasmodium falciparum severity in Malian children
Tissue Antigens, Volume 77, No. 6, Year 2011
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Description
Pre-erythrocytic immunity to Plasmodium falciparum malaria is likely to be mediated by T-cell recognition of malaria epitopes presented on infected host cells via class I and II major histocompatibility complex (MHC) antigens. To test for associations of human leukocyte antigen (HLA) alleles with disease severity, we performed high-resolution typing of HLA class I and II loci and compared the distributions of alleles of HLA-A, -B, -C and -DRB1 loci in 359 Malian children of Dogon ethnicity with uncomplicated or severe malaria. We observed that alleles A*30:01 and A*33:01 had higher frequency in the group of patients with cerebral disease compared to patients with uncomplicated disease [A*30:01: gf = 0.2031 vs gf = 0.1064, odds ratio (OR) = 3.17, P = 0.004, confidence interval (CI) (1.94-5.19)] and [A*33:01: gf = 0.0781 vs gf = 0.0266, 4.21, P = 0.005, CI (1.89-9.84)], respectively. The A*30:01 and A*33:01 alleles share some sequence motifs and A*30:01 appears to have a unique peptide binding repertoire compared to other A*30 group alleles. Computer algorithms predicted malaria peptides with strong binding affinity for HLA-A*30:01 and HLA-A*33:01 but not to closely related alleles. In conclusion, we identified A*30:01 and A*33:01 as potential susceptibility factors for cerebral malaria, providing further evidence that polymorphism of MHC genes results in altered malaria susceptibility. © 2011 John Wiley & Sons A/S.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3152196/bin/tan0077-0562-SD1.doc
Authors & Co-Authors
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Fernández-Viña, Marcelo Aníbal
United States, Houston
University of Texas Health Science Center at Houston
Cao, K.
United States, Los Angeles
Cedars-sinai Medical Center
United States, Washington, D.c.
Georgetown University Medical Center
Hollenbach, Jill Allison
United States, Oakland
Children's Hospital Oakland Research Institute
Coulibaly, Drissa M.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Koné, Abdoulaye Kassoum
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Guindo, A.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Burdett, Laurie A.
United States, Rockville
National Cancer Institute Nci
United States, Frederick
Saic-frederick
Hartzman, Robert J.
United States, Washington, D.c.
Georgetown University
Wahl, A. R.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Hildebrand, William H.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Sztein, Marcelo B.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 50
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1111/j.1399-0039.2011.01661.x
ISSN:
00012815
e-ISSN:
13990039
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study