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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Soluble Fas and gonadal hormones in infertile men with varicocele
Fertility and Sterility, Volume 91, No. 2, Year 2009
Notification
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Description
Objective: To assess gonadal hormones in serum and semen as well as seminal antiapoptotic factor; soluble fibroblast associated (sFas) in infertile men associated with scrotal varicocele. Design: Prospective. Setting: Academic setting. Patients: Eighty-eight males: fertile healthy controls (Gr1, n = 12), fertile normozoospermia with varicocele (Gr2, n = 31), and infertile oligoasthenozoospermia with varicocele (Gr3, n = 45). Main Outcome Measure(s): Serum and seminal gonadal hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and testosterone (T), in addition to seminal sFas. Results: There were significant higher mean levels of serum FSH, serum, and seminal LH with significant lower seminal T levels in cases of Gr3 compared with Gr2. Mean seminal sFas in Gr3 were significantly higher than its levels in Gr1 and 2 (mean ± SE 8.34 ± 0.36 vs. 6.8 ± 0.53 and 6.06 ± 0.39 ng/mL, respectively). Nonsignificant differences between serum and seminal gonadal hormones were elicited between Gr2 and controls. Seminal sFas in various varicocele grades demonstrated nonsignificant differences. There were significant positive correlations between seminal sFas with serum FSH, serum LH, semen FSH, sperm abnormal forms percentage, and significant negative correlations with sperm concentration and sperm motility. Conclusion(s): sFas could play a role in germ cell apoptosis in varicocele-associated cases. © 2009 American Society for Reproductive Medicine.
Authors & Co-Authors
Zedan, Hatem M.
Egypt, Asyut
Faculty of Medicine
El-Mekhlafi, Abdel Wasea M.M.
Egypt, Asyut
Faculty of Medicine
El-Noweihi, Amira M.
Egypt, Asyut
Faculty of Medicine
Abd El-Azim, Nagwa E.
Egypt, Asyut
Faculty of Medicine
Mostafa, Taymour M.
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 31
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.fertnstert.2007.11.090
ISSN:
00150282
Research Areas
Cancer
Health System And Policy
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male