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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Altered antioxidant defense system in clinically stable patients with schizophrenia and their unaffected siblings
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 32, No. 1, Year 2008
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Description
Objective: To determine Red Blood Cell (RBC) antioxidant enzyme activities and plasma Thiobarbituric Acid Reactive Substances (TBARS) in clinically stable patients with schizophrenia and their unaffected siblings. Methods: A case-control study carried out on three groups: 60 schizophrenic patients treated with neuroleptics, 33 of their unaffected siblings and 30 healthy controls with no family psychiatric history. Biological markers were measured on fasting patients after a period of tobacco abstinence: RBC antioxidant enzyme activities - superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) - by spectrophotometry and plasma levels of TBARS by spectrofluorimetry. Results: RBC SOD and CAT activities were significantly lower in schizophrenic patients and their unaffected siblings compared to the control group (P < 0.001). Schizophrenic patients also had significantly lower RBC GSH-Px activity than controls (P = 0.03), whereas their unaffected siblings had significantly higher RBC GSH-Px activity than controls (P = 0.04). Plasma TBARS were higher in schizophrenic patients than their unaffected siblings: 2.1 ± 0.8 μmol/l vs. 1.7 ± 0.6 μmol/l (P = 0.06). Conclusions: Our results showed a decrease in antioxidant enzyme activities and an increase in lipid peroxidation confirming the existence of oxidative stress in schizophrenic patients treated with neuroleptics. Additionally, this suggests that the increase in GSH-Px activity in unaffected siblings would be a protective mechanism against oxidative stress and damage. Other studies are necessary to confirm these findings. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ben Othmen, Leila
Tunisia, Monastir
Free Radicals and Antioxidants
Mechri, A.
Tunisia, Monastir
Université de Monastir
Fendri, Chiraz
Tunisia, Monastir
Université de Monastir
Bost, Muriel
France, Lyon
Trace Element Institute for Unesco
Chazot, Guy
France, Lyon
Trace Element Institute for Unesco
Gaha, Lotfi
Tunisia, Monastir
Université de Monastir
Kerkeni, Abdelhamid
Tunisia, Monastir
Free Radicals and Antioxidants
Statistics
Citations: 107
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.pnpbp.2007.08.003
ISSN:
02785846
Research Areas
Mental Health
Substance Abuse
Study Design
Randomised Control Trial
Case-Control Study