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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Amnioinfusion for the prevention of the meconium aspiration syndrome
New England Journal of Medicine, Volume 353, No. 9, Year 2005
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Description
BACKGROUND: It is uncertain whether amnioinfusion (infusion of saline into the amniotic cavity) in women who have thick meconium staining of the amniotic fluid reduces the risk of perinatal death, moderate or severe meconium aspiration syndrome, or both. METHODS: We performed a multicenter trial in which 1998 pregnant women in labor at 36 or more weeks of gestation who had thick meconium staining of the amniotic fluid were stratified according to the presence or absence of variable decelerations in fetal heart rate and then randomly assigned to amnioinfusion or to standard care. The composite primary outcome measure was perinatal death, moderate or severe meconium aspiration syndrome, or both. RESULTS: Perinatal death, moderate or severe meconium aspiration syndrome, or both occurred in 44 infants (4.5 percent) of women in the amnioinfusion group and 35 infants (3.5 percent) of women in the control group (relative risk, 1.26; 95 percent confidence interval, 0.82 to 1.95). Five perinatal deaths occurred in the amnioinfusion group and five in the control group. The rate of cesarean delivery was 31.8 percent in the amnioinfusion group and 29.0 percent in the control group (relative risk, 1.10; 95 percent confidence interval, 0.96 to 1.25). CONCLUSIONS: For women in labor who have thick meconium staining of the amniotic fluid, amnioinfusion did not reduce the risk of moderate or severe meconium aspiration syndrome, perinatal death, or other major maternal or neonatal disorders. Copyright © 2005 Massachusetts Medical Society. All rights reserved.
Authors & Co-Authors
Fraser, William Donald
Unknown Affiliation
Hofmeyr, George Justus
Unknown Affiliation
Lede, Roberto L.
Unknown Affiliation
Faron, Gilles
Unknown Affiliation
Alexander, S.
Unknown Affiliation
Goffinet, François O.
Unknown Affiliation
Ohlsson, Arne
Unknown Affiliation
Goulet, Céline
Unknown Affiliation
Turcot-Lemay, Lucile
Unknown Affiliation
Prendiville, Walter J.P.
Unknown Affiliation
Marcoux, Sylvie
Unknown Affiliation
Laperrière, Louise
Unknown Affiliation
Roy, Chantal
Unknown Affiliation
Petrou, Stavros
Unknown Affiliation
Xu, Hai Rong
Unknown Affiliation
Wei, Bin
Unknown Affiliation
Statistics
Citations: 22
Authors: 16
Affiliations: 13
Identifiers
Doi:
10.1056/NEJMoa050223
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Participants Gender
Female