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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Sero-diagnosis of tuberculosis with A60 antigen enzyme-linked immunosorbent assay: failure in HIV-infected individuals in Ghana
Medical Microbiology and Immunology, Volume 181, No. 2, Year 1992
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Description
In order to assess the diagnostic usefulness of the A60 (ANDA Biologicals, Strassbourg, France) sero-diagnostic enzyme-linked immunosorbent assay (ELISA) kit for tuberculosis in Africa, sera of 53 pulmonary smear-positive tuberculosis (TB) patients, 30 apparently healthy control subjects and 6 AIDS suspects were sampled in Agogo Hospital in the forest area of Ghana. These sera were analyzed for antibodies to HIV-1 and HIV-2, and IgG-antibodies to the A60 BCG-antigen, while the non-HIV individuals were tested for total IgG levels. One healthy control subject, all of 6 AIDS suspects and 7 of the TB patients has HIV infections. In the non-HIV TB group, the sensitivity and specifity of the A60 ELISA was 78% and 86%, respectively, which was much poorer than expected from published reports about the A60 test. The A60 test failed, completely however, to discriminate between TB and non-TB in the HIV-positive group. In the non-HIV groups, total IgG levels were significantly higher in TB patients than in controls. It seems that the usefulness of the A60 ELISA test to diagnose tuberculosis is very limited in this high-incidence area, and that it seems to be of no value in patients infected with HIV. © 1992 Springer-Verlag.
Authors & Co-Authors
Van Derwerf, Tjip S.
Ghana, Agogo
Agogo Presbyterian Hospital
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Das, P. K.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
van Soolingen, Dick
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Yong, S.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Mark, Thomas W.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
van den Akker, R.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Statistics
Citations: 19
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1007/BF00189425
ISSN:
03008584
e-ISSN:
14321831
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Ghana