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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
PLoS Pathogens, Volume 4, No. 3, Article e1000033, Year 2008
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Description
One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL responses may have lower fitness than the wild-type and can be associated with slower disease progression. Transmission of the escape variant to individuals without these HLA alleles is associated with rapid reversion to wild-type. However, the question of whether infection with an escape mutant offers an advantage to newly infected hosts has not been addressed. Here we investigate the relationship between the genotypes of transmitted viruses and prognostic markers of disease progression and show that infection with HLA-B*57/B*5801 escape mutants is associated with lower viral load and higher CD4+ counts. © 2008 Chopera et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2265427/bin/ppat.1000033.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2265427/bin/ppat.1000033.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC2265427/bin/ppat.1000033.s003.doc
Authors & Co-Authors
Chopera, Denis R.
South Africa, Cape Town
University of Cape Town
Woodman, Zenda L.
South Africa, Cape Town
University of Cape Town
Mlisana, Koleka P.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Mlotshwa, Mandla
South Africa, Johannesburg
National Institute for Communicable Diseases
Martin, Darren Patrick
South Africa, Cape Town
University of Cape Town
Seoighe, Cathal
South Africa, Cape Town
University of Cape Town
Treurnicht, F. K.
South Africa, Cape Town
University of Cape Town
De Rosa, Debra Assis
South Africa, Johannesburg
National Institute for Communicable Diseases
Hide, Winston A.
South Africa, Bellville
University of the Western Cape
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Gray, Clive M.
South Africa, Johannesburg
National Institute for Communicable Diseases
Williamson, Carolyn
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 157
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1371/journal.ppat.1000033
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Genetics And Genomics
Infectious Diseases