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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries
Science, Volume 207, No. 4432, Year 1980
Notification
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Description
An abnormal extra band was found on the short arm of the X chromosome in a 46,XY female and in her 46,XY female fetal sibling. Despite presence of the intact Y chromosome, there was no evidence of testicular differentiation in either subject. Production of H-Y antigen was suppressed in both subjects. The data suggest that development of the mammalian testis requires a normal function of the X chromosome. Copyright © 1980 AAAS.
Authors & Co-Authors
Bernstein, Renée
South Africa, Johannesburg
School of Pathology
Koo, Gloria C.
United States, New York
Memorial Sloan-kettering Cancer Center
Wachtel, Stephen S.
United States, New York
Weill Cornell Medical Center
Statistics
Citations: 75
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1126/science.7352285
ISSN:
00368075
Participants Gender
Female