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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
-308G>A and -1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease
Clinical Chemistry and Laboratory Medicine, Volume 47, No. 10, Year 2009
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Description
Background: Recent research has shown that inflammation plays a key role in coronary artery disease (CAD) and other manifestations of atherosclerosis. Several lines of evidence support a key role for tumor necrosis factor-α (TNF-α), a potent immunomodulator and pro-inflammatory cytokine, in the development of atherosclerosis and in complications of CAD. Methods: We investigated the possible association between CAD and the TNF gene promoter polymorphisms -308G>A and -1031T>C in a Tunisian population. We compared the distribution of these polymorphisms between 418 patients with CAD and 406 healthy controls using polymerase chain reaction restriction fragment length-polymorphism analysis. Results: The frequency of the TNF-α -308A allele in the control group was similar to that observed in CAD patients [p=0.78; odds ratio (OR)=1.15; 95% confidence interval (CI)=0.86-1.55], but higher than those described in other Europeans, such as in the French, Finnish and Spanish. Concerning the TNF-α -1031T/C polymorphism, the same distribution was observed between patients with CAD and controls (p=0.12; OR=1.27; 95% CI=0.94-1.72). In addition, the genotype and allele frequencies of control individuals were comparable to those previously reported in healthy Tunisian controls and other ethnic groups. Haplotype analysis (TNF-α -308G>A and -1031T>C) demonstrated no significant association between TNF haplotypes and CAD. Conclusions: We conclude that TNF promoter gene polymorphisms at position -308G>A and -1031T>C do not play a major role in the pathogenesis of CAD in the Tunisian population. © 2009 by Walter de Gruyter Berlin New York.
Authors & Co-Authors
Ghazouani, Lakhdar
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Khalifa, Sonia Ben Hadj
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Abboud, Nesrine
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Addad, Faouzi
Tunisia, Monastir
Chu Fattouma-bourguiba
Khalfallah, Ali Ben
Tunisia, Bizerte
Hôpital Menzel Bourguiba
Brahim, Nsiri
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mediouni, Mounira
Tunisia
Hospital Center of Jendouba
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 25
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1515/CCLM.2009.287
ISSN:
14346621
e-ISSN:
14374331
Research Areas
Cancer
Genetics And Genomics
Study Design
Randomised Control Trial
Cross Sectional Study
Case-Control Study