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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosis and monitoring of HIV-1 group o-infected patients in cameroun
Journal of Acquired Immune Deficiency Syndromes, Volume 53, No. 1, Year 2010
Notification
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Description
OBJECTIVE: To define a routine algorithm for the specific diagnosis and complete follow-up of HIV-1 group O (HIV-O) infections in Cameroun. METHODS: During 18 months, samples referred to Centre Pasteur du Cameroun for HIV testing or viral monitoring were screened for HIV-O infection with an in-house serotyping assay. HIV-O viral load was quantified by real-time polymerase chain reaction in the LTR gene and resistance genotyping was performed on pol and env sequences. RESULTS: Of the 7030 samples tested, 78 HIV-O infections (1.1%) were identified, including 7 M and O dually seroreactive samples (9%). All treatment-naive patients and 59% of the patients receiving HAART had detectable viral loads. Analysis of pol sequences from 15 treatment-naive patients revealed a high number of polymorphisms in the protease region, with natural residues implicated in genotypic resistance to tipranavir and saquinavir for HIV-1 group M according to the Agence Nationale de Recherches sur le Sida et les Hépatites virales algorithm. Six patients (40%) harbored the 181C mutation conferring natural resistance to nonnucleoside reverse transcriptase inhibitors. Among antiretroviral-treated patients, major resistance mutations described for HIV-1 group M were found. CONCLUSIONS: HIV-O prevalence remains relatively low in Cameroun. The cocirculation of groups M and O in this country leads to replicative dual infections. HIV-O-infected patients in this region can now benefit from effective and specific tools for a complete monitoring of infection. However, further studies are needed to understand long-term response to antiretrovirals of these complex variants. Copyright © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Vessiére, Aurélia
Cameroon, Yaounde
Centre Pasteur du Cameroun
Rousset, Dominique
Cameroon, Yaounde
Centre Pasteur du Cameroun
Kfutwah, Anfumbom Kitu Womeyi
Cameroon, Yaounde
Centre Pasteur du Cameroun
Leoz, Marie
Cameroon, Yaounde
Centre Pasteur du Cameroun
Depatureaux, Agnès Geremy
France, Rouen
Hopital Charles Nicolle
Simon, Franćois
France, Paris
Hôpital Saint-louis
Plantier, Jean Christophe
France, Rouen
Hopital Charles Nicolle
Statistics
Citations: 57
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e3181b97ec1
ISSN:
15254135
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study