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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increases in levels of schistosome-specific immunoglobulin E and CD23
+
B cells in a cohort of kenyan children undergoing repeated treatment and reinfection with schistosoma mansoni
Journal of Infectious Diseases, Volume 202, No. 3, Year 2010
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Description
Background. Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to determine whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection. Methods. Children (8-10 years old) were tested for S. mansoni every 4 months and treated with praziquantel when positive (arm A; ) or were tested and treated at the end of the 2-year follow-up np68 period (arm B; np49). Results. Children in arm A who remained free of infection during follow-up had significantly higher baseline levels of schistosome-specific immunoglobulin E (IgE) than did children with ≥2 repeat diagnoses of S. mansoni infection. Children with ≥2 repeat diagnoses of S. mansoni infection had significantly increased levels of antischistosome IgE and CD23+ B cells after receiving ≥3 praziquantel treatments over the course of follow-up. No increase in either parameter was seen in children who received only the baseline praziquantel treatment. Conclusions. B cell activation and anti-schistosome IgE are associated with resistance to S. mansoni in children, and these immunological parameters can be increased by multiple rounds of infections and praziquantel-induced cures. © 2010 by the Infectious Diseases Society of America.
Authors & Co-Authors
Black, Carla L.
United States, Athens
University of Georgia
Muok, Erick Mbata O.
Kenya, Nairobi
Kenya Medical Research Institute
Mwinzi, Pauline Ngina M.
Kenya, Nairobi
Kenya Medical Research Institute
Carter, Jennifer M.
United States, Athens
University of Georgia
Karanja, Diana M.Sabwa
Kenya, Nairobi
Kenya Medical Research Institute
Secor, William Evan
United States, Atlanta
Centers for Disease Control and Prevention
Colley, Daniel G.
United States, Athens
University of Georgia
Statistics
Citations: 62
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1086/653828
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative