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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diathermy-induced injury may affect detection of occult tubal lesions at risk-reducing salpingo-oophorectomy
International Journal of Gynecological Cancer, Volume 22, No. 5, Year 2012
Notification
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Description
Background: Electrosurgery-induced tubal thermal injury obscures cellular detail and hampers histomorphological assessment for occult pathology. Objective: The objectives of this study were to report on diathermy-related thermal injuries to the fallopian tube observed at RRSO and explore its potential impact on the detection of occult tubal epithelial lesions. Design: This study was composed of high-risk women from breast and/or ovarian cancer families attending a tertiary high-risk familial gynecologic cancer clinic. This was a retrospective case-control analysis of high-risk women who underwent RRSO. Cases were all women detected to have occult lesions (tubal atypia/carcinoma in situ/cancer) between January 2005 and December 2010. Control subjects were all women with normal tubal/ ovarian histology between August 2006 and December 2007. Methods: Two pathologists performed histopathologic assessment for grade of thermal injury. Tubal diathermy injury rates were compared between cases and controls. Statistical analysis was undertaken using SPSS version 18. The Mann-Whitney U test compared age distributions; W 2 /Fisher tests, the difference between proportions, and F test, the difference in ordinal variables between the groups. Results: A novel tubal thermal index to describe the severity of injury is reported. Lack of fimbrial thermal injury is twice as likely (odds ratio, 2.04; 95% confidence interval, 1.06Y3.92) to be associated with detection of occult tubal pathology, whereas isthmic injury does not affect detection rate (P = 0.744). The groups were comparable with respect to age at RRSO (P = 0.531) and the presence of BRCA mutations (P = 0.192). Conclusions: This report highlights the potential impact of electrosurgical thermal injury on detection of occult tubal pathology following RRSO. It is important for surgeons to avoid thermal injury to the distal end of the tube. © 2012 by IGCS and ESGO.
Authors & Co-Authors
Manchanda, Ranjit
United Kingdom, London
University College London
Silvanto, Anna
United Kingdom, London
University College London
Abdelraheim, Ahmed R.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Egypt, Minya
Al-minya University Hospital
Burnell, Matthew
United Kingdom, London
University College London
Johnson, Michelle
United Kingdom, London
University College London
Saridoǧan, Ertan
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Rosenthal, Adam N.
United Kingdom, London
University College London
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Brunell, Carol
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Aslam, Naaila
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Vashisht, Arvind
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Pandis, George
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Jacobs, Ian J.
United Kingdom, London
University College London
United Kingdom, Manchester
Faculty of Biology, Medicine and Health
Menon, Usha
United Kingdom, London
University College London
Benjamin, Elizabeth
United Kingdom, London
University College London
Statistics
Citations: 14
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1097/IGC.0b013e31824b4093
ISSN:
1048891X
e-ISSN:
15251438
Research Areas
Cancer
Health System And Policy
Violence And Injury
Study Design
Cohort Study
Case-Control Study
Study Approach
Quantitative
Participants Gender
Female