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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2
Nature Medicine, Volume 27, No. 8, Year 2021
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Description
Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)—the Pfizer-BioNTech mRNA COVID-19 vaccine—in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-γ/IL-2R/IL-18/IL-16/IL-10) and steroid responsiveness. The close temporal association of vaccination and diagnosis of CRS in this case suggests that CRS was a vaccine-related adverse event; with anti-PD1 blockade as a potential contributor. Overall, further prospective pharmacovigillence data are needed in patients with cancer, but the benefit–risk profile remains strongly in favor of COVID-19 vaccination in this population. © 2021, The Author(s).
Authors & Co-Authors
Au, Lewis
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Fendler, Annika
United Kingdom, London
The Francis Crick Institute
Shepherd, Scott T.C.
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Rzeniewicz, Karolina
United Kingdom, London
The Francis Crick Institute
Cerrone, Maddalena
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
Imperial College London
Byrne, Fiona
United Kingdom, London
The Francis Crick Institute
Carlyle, Eleanor
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Edmonds, Kim
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
del Rosario, Lyra
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Shon, John C.
Unknown Affiliation
Ward, Barry
United Kingdom, London
The Francis Crick Institute
Shum, Benjamin
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Gordon, William
United Kingdom, London
The Francis Crick Institute
Xie, Wenyi
United Kingdom, London
The Francis Crick Institute
Joharatnam-Hogan, Nalinie
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Pickering, Lisa M.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Furness, Andrew J.S.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Larkin, James M.G.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Harvey, Ruth
United Kingdom, London
The Francis Crick Institute
Kassiotis, George
United Kingdom, London
The Francis Crick Institute
Gandhi, Sonia
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
Ucl Queen Square Institute of Neurology
Swanton, Charles
United Kingdom, London
The Francis Crick Institute
Swanton, Charles
United Kingdom, London
The Francis Crick Institute
Fribbens, Charlotte V.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Andrea Wilkinson, Katalin Andrea
United Kingdom, London
The Francis Crick Institute
Wilkinson, Robert J.
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
Imperial College London
Lau, David K.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Starling, Naureen
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Chau, Ian Yin Yan
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Gérard, Camille Lea
United Kingdom, London
The Francis Crick Institute
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Young, Kathleen
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Banerjee, Susana N.
United Kingdom, London
The Institute of Cancer Research
Turajlic, Samra
United Kingdom, London
The Francis Crick Institute
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Statistics
Citations: 57
Authors: 33
Affiliations: 6
Identifiers
Doi:
10.1038/s41591-021-01387-6
ISSN:
10788956
Research Areas
Cancer
Covid
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study