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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Arginine- vasopressin in postpartum panhypopituitarism: Urinary excretion and kidney response to osmolar load
Journal of Clinical Endocrinology and Metabolism, Volume 58, No. 3, Year 1984
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Description
The response to an osmolar load (750 ml 2.5% NaCl solution iv preceded by 500 ml water by mouth) was studied n i 20 patients with Sheehan’s syndrome and 12 normal women. Sodium and osmolality were determined in plasma and urine and arginine-vasopressin (AVP) was measured by RIA in urine. The test was performed in each patient when untreated (group P), after hydrocortisone replacement alone (group F), and combined hydrocortisone and thyroid hormone replacement (group F+T). After the osmolar loading, maximum urinary osmolality n i the patients was lower than in the normal women and remained unaffected by both hydrocortisone alone and hydrocor-tisone and thyroid hormone. Comparison of the mean hourly urinary volume before and after NaCl infusion demonstrated an increase in group P, a decrease in group C, and no change in groups F and F+T. Although free water clearance became negative in all groups, values in groups P, F, and F+T were constantly above that of group C. None of the patients in groups P and F had a significant rise in urine AVP excretion during or after NaCl infusion. Those in group F+T had a slight AVP response which was less than in normal women. Impaired response of AVP to an osmolar load appears to be a constant feature of Sheehan’s syndrome even without overt diabetes insipidus. © 1984 by The Endocrine Society.
Authors & Co-Authors
Bakiri, Fawzi
Algeria, Algiers
Centre Pierre et Marie Curie
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Benmiloud, Moulay
Algeria, Algiers
Centre Pierre et Marie Curie
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Vallotton, Michael B.
Algeria, Algiers
Centre Pierre et Marie Curie
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Statistics
Citations: 25
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1210/jcem-58-3-511
ISSN:
0021972X
e-ISSN:
19457197
Research Areas
Environmental
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Participants Gender
Female