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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Improved treatment satisfaction and convenience with deferasirox in iron-overloaded patients with β-thalassemia: Results from the ESCALATOR trial
Acta Haematologica, Volume 123, No. 4, Year 2010
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Description
Patient-reported outcomes of once-daily oral deferasirox (Exjade®) in iron-overloaded patients with β-thalassemia not achieving successful chelation with prior deferoxamine and/or deferiprone were investigated in a prospective, open-label, 1-year, multicenter study in the Middle East (ESCALATOR). The initial dose of deferasirox was 20 mg/kg/day, with subsequent dose adjustments. At baseline and the end of study (EOS), patients (n = 237) completed a 5-point rating scale for treatment satisfaction and convenience, and recorded time lost to treatment. At EOS, 90.7% of patients were 'satisfied'/'very satisfied' with their iron chelation therapy (ICT) versus 23.2% at baseline. 92.8% (EOS) versus 21.5% (baseline) of patients considered their therapy to be 'convenient'/'very convenient'. Time lost to therapy for daily activities was substantially reduced (3.2 ± 8.6 [mean ± SD; EOS] vs. 30.1 ± 44.2 [baseline] h/month). Patients reported greater satisfaction and convenience, and lower impact on daily activities, with deferasirox than with previous ICT. This may help improve adherence to lifelong ICT in iron-overloaded β-thalassemia patients. © 2010 S. Karger AG, Basel.
Authors & Co-Authors
Taher, Ali T.
Lebanon, Beirut
American University of Beirut Medical Center
Al-Jefri, Abdullah Hussain
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
ElAlfy, Mohsen Saleh
Egypt, Cairo
Ain Shams University
Al-Zir, Kusai Nasser
Syrian Arab Republic, Damascus
National Thalassemia Center
Daar, Shahina F.
Oman, Muscat
Sultan Qaboos University
Rofail, Diana
United States, Boston
Mapi Values
Baladi, Jean François
Switzerland, Basel
Novartis International ag
Habr, Dany
Switzerland, Basel
Novartis International ag
Kriemler-Krahn, Ulrike
Switzerland, Basel
Novartis International ag
El-Beshlawy, Amal M.
Egypt, Giza
Cairo University
Statistics
Citations: 52
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1159/000313447
ISSN:
00015792
Research Areas
Health System And Policy
Study Design
Cohort Study