Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three african populations
PLoS ONE, Volume 4, No. 1, Article e4206, Year 2009
Notification
URL copied to clipboard!
Description
Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type responses. It is therefore likely to be crucial in both innate and adaptive responses against intracellular pathogens such as Plasmodium falciparum. Polymorphisms at the human IRF1 locus have been previously found to be associated with the ability to control P. falciparum infection in populations naturally exposed to malaria. In order to test whether genetic variation at the IRF1 locus also affects the risk of developing severe malaria, we performed a family-based test of association for 18 Single Nucleotide Polymorphisms (SNPs) across the gene in three African populations, using genotype data from 961 trios consisting of one affected child and his/her two parents (555 from The Gambia, 204 from Kenya and 202 from Malawi). No significant association with severe malaria or severe malaria subphenotypes (cerebral malaria and severe malaria anaemia) was observed for any of the SNPs/haplotypes tested in any of the study populations. Our results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria. © 2009 Mangano et al.
Authors & Co-Authors
Mangano, Valentina Dianora
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Italy, Rome
Sapienza Università Di Roma
Clark, Taane Gregory
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
Auburn, Sarah A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
Campino, Susana G.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
Diakité, Mahamadou L.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Fry, Andrew E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Green, Angie L.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Richardson, Anna
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Jallow, Muminatou
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sisay-Joof, Fatoumatta
Gambia, Banjul
Medical Research Council Laboratories Gambia
Pinder, Margaret
Gambia, Banjul
Medical Research Council Laboratories Gambia
Griffiths, Michael John
Kenya, Nairobi
Kenya Medical Research Institute
Newton, Charles R.J.C.
Kenya, Nairobi
Kenya Medical Research Institute
Peshu, Norbert M.
Kenya, Nairobi
Kenya Medical Research Institute
Williams, Thomas Neil
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, Oxford
John Radcliffe Hospital
Marsh, Kevin
Kenya, Nairobi
Kenya Medical Research Institute
United Kingdom, Oxford
John Radcliffe Hospital
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Taylor, Terrie Ellen
Malawi, Zomba
University of Malawi
United States, East Lansing
Msu College of Osteopathic Medicine
Modiano, David
Italy, Rome
Sapienza Università Di Roma
Kwiatkowski, Dominic P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
Rockett, Kirk A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 58
Authors: 21
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0004206
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Gambia
Kenya
Malawi