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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria
Human Immunology, Volume 72, No. 1, Year 2011
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Description
Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promoter SNPs (-986G>A, -602G>A, and -4A>G) and one single nucleotide polymorphisms (SNP) in exon 8 (+6424G>T) using quantitative TaqMan, real-time polymerase chain reaction (PCR). In addition, we measured the ficolin-2 plasma levels at two time points: on admission (t 0, acute disease) and 4 weeks after treatment (t 1, healthy phase). Comparison of ficolin-2 plasma levels shows that ficolin-2 concentration is highest during acute severe disease. In addition, we determined polymorphisms in the promoter and all coding regions of FCN2 in 40 Gabonese. Linkage disequilibrium data revealed polymorphic allelic combination patterns in the FCN2 promoter region; strong allelic combinations at -986 and -4, and -557 and -64 were found. No FCN2 promoter haplotypes were significantly distributed between mild and severe cases. © 2011 American Society for Histocompatibility and Immunogenetics.
Authors & Co-Authors
Faik, Imad
Germany, Tubingen
Eberhard Karls Universität Tübingen
Oyedeji, Segun Isaac
Germany, Tubingen
Eberhard Karls Universität Tübingen
Idris, Zulkarnain Md
Germany, Tubingen
Eberhard Karls Universität Tübingen
Malaysia, Minden
Institute for Research in Molecular Medicine
de Messias-Reason, Iara José T.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lell, Bertrand
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Kun, Juergen F.J.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 29
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.humimm.2010.10.003
ISSN:
01988859
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative
Study Locations
Gabon