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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV incidence in young girls in KwaZulu-Natal, South Africa-public health imperative for their inclusion in HIV biomedical intervention trials
AIDS and Behavior, Volume 16, No. 7, Year 2012
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Description
Young women are particularly vulnerable for acquiring HIV yet they are often excluded from clinical trials testing new biomedical intervention. We assessed the HIV incidence and feasibility of enrolling a cohort of young women for potential participation in future clinical trials. Between March 2004 and May 2007, 594 HIV uninfected 14-30 year old women were enrolled into a longitudinal HIV risk reduction study in KwaZulu-Natal, South Africa. The overall HIV prevalence at screening in young girls below the age of 18 years was 27.6 % compared to 52.0 % in the women above 18 years, p<0.001. HIV incidence was 4.7 ≥95 % Confidence interval (CI) 1.5-10.9) and 6.9 (95 % CI 4.8-9.6)/100 women years (wy), p = 0.42 and pregnancy rates were 23.7 (95 % CI 14.9-35.9) and 16.4 (95 % CI 12.9-20.6)/100 wy, p = 0.29, in the women below and above 18 years respectively. Retention was similar in both groups (71.0 vs. 71.5 %, p = 0.90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17 years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study. © Springer Science+Business Media, LLC 2012.
Authors & Co-Authors
Abdool Karim, Quarraisha Abdool
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Mailman School of Public Health
Kharsany, Ayesha B.M.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Fröhlich, Janet A.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Werner, Lise
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Mlotshwa, Mukelisiwe
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Madlala, Bernadette T.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
Abdool Karim, Salim S.
South Africa, Congella
Centre for the Aids Programme of Research in South Africa
United States, New York
Mailman School of Public Health
Statistics
Citations: 67
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1007/s10461-012-0209-y
ISSN:
10907165
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
South Africa
Participants Gender
Female