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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Detection of emerging genotypes in Trichophyton mentagrophytes species complex: A proposal for handling biodiversity in dermatophytes
Frontiers in Microbiology, Volume 13, Article 960190, Year 2022
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Description
A resistant and hypervirulent dermatophyte from India has been described as a taxonomic novelty, Trichophyton indotineae, a species of the Trichophyton mentagrophytes complex. Rapid detection and correct identification of closely similar dermatophytes with different predilections are essential for efficient clinical management. We evaluated the efficacy of rapid diagnostic methods clinical and environmental strains in the T. mentagrophytes complex. The methods included Real-time-PCR, DermaGenius, LAMP, and MALDI-ToF MS, using rDNA ITS sequences as taxonomic standard. The results show that only MALDI-ToF MS can distinguish 96.97% T. indotineae from other closely related species. The complex comprises numerous clones which may differ in anonymous markers but with similar evolutionary behavior. Therefore, we recommend to distinguish species only when they show an appreciable degree of adaptation and thus are clinically significant. The distinction of remaining clonal diversity is an epidemiological query and can be solved by haplotype numbering. Copyright © 2022 Tang, Ahmed, Deng, Zhang, Zoll, Al-Hatmi, Meis, Thakur, Kang and de Hoog.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9445586/bin/Table_1.DOCX
https://efashare.b-cdn.net/share/pmc/articles/PMC9445586/bin/Table_2.DOCX
https://efashare.b-cdn.net/share/pmc/articles/PMC9445586/bin/Presentation_1.PPTX
Authors & Co-Authors
Ahmed, Sarah A.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Deng, Shuwen
Unknown Affiliation
Al-Hatmi, Abdullah M.S.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Oman, Nizwa
University of Nizwa
Meis, Jacques F.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Brazil, Curitiba
Universidade Federal do Parana
Kang, Yingqian
China, Beijing
Ministry of Education of the People's Republic of China
de Hoog, Gerrits Sybren
China, Beijing
Ministry of Education of the People's Republic of China
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Oman, Nizwa
University of Nizwa
Statistics
Citations: 15
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.3389/fmicb.2022.960190
ISSN:
1664302X
Research Areas
Genetics And Genomics