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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Investigation on chemical composition, anticholinesterase and antioxidant activities of extracts and essential oils of Turkish Pinus species and pycnogenol
Industrial Crops and Products, Volume 38, No. 1, Year 2012
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Description
In the current work, the acetone, ethyl acetate, and ethanol extracts and essential oils of the twigs and needles of five Turkish Pinus species; P. brutia, P. halepensis, P. nigra, P. pinea, and P. sylvestris along with pycnogenol (the bark extract of P. pinaster) were examined for their inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at 200μgmL -1. Their antioxidant activity was tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N-dimethyl-p-phenylendiamine (DMPD) radical scavenging, metal-chelation, and ferric-reducing antioxidant power (FRAP) assays. Total phenol and flavonoid contents of the extracts were determined by Folin-Ciocalteau and AlCl 3 reagents, respectively. GC-MS technique was applied for compositional profile of the essential oils of the tested species. Accordingly, the best AChE and BChE inhibition was caused by the twig essential oil (83.91±3.95%) and the needle ethanol extract (82.47±5.57%) of P. halepensis, respectively. Pycnogenol also caused a remarkable inhibition against AChE (63.33±0.22%) and BChE (83.67±0.22%). The extracts and essential oils usually showed a strong activity in the antioxidant assays. Pycnogenol exhibited a potent antioxidant effect and had the richest total phenol content. In the essential oils, α- and β-pinene were identified the major components. These results reveal that the Pinus species and pycnogenol are the potential sources of active metabolites with cholinesterase and antioxidant properties. © 2012 Elsevier B.V.
Authors & Co-Authors
Ustun, Osman
Turkey, Ankara
Gazi Üniversitesi
Senol Deniz, F. Sezer
Turkey, Ankara
Gazi Üniversitesi
Kürkçüoĝlu, Mine K.
Turkey, Eskisehir
Anadolu Üniversitesi
Orhan, I. E.
Turkey, Ankara
Gazi Üniversitesi
Turkey, Famagusta
Eastern Mediterranean University
Kartal, M.
Turkey, Ankara
Ankara Üniversitesi
Başer, K. Hüsnü Can
Turkey, Eskisehir
Anadolu Üniversitesi
Saudi Arabia, Riyadh
College of Sciences
Statistics
Citations: 78
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.indcrop.2012.01.016