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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP
iScience, Volume 26, No. 12, Article 108574, Year 2023
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Description
The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the rVSVΔG-ZEBOV-GP vaccine or placebo, we profiled intracellular microRNAs (miRNAs) from whole blood cells (WB) and circulating miRNAs from serum-derived extracellular vesicles (EV) at baseline and longitudinally following vaccination. Further, we identified early miRNA signatures associated with ZEBOV-specific IgG antibody responses at baseline and up to one year post-vaccination, and pinpointed target mRNA transcripts and pathways correlated to miRNAs whose expression was altered after vaccination by using systems biology approaches. Several miRNAs were differentially expressed (DE) and miRNA signatures predicted high or low IgG ZEBOV-specific antibody levels with high classification performance. The top miRNA discriminators were WB-miR-6810, EV-miR-7151-3p, and EV-miR-4426. An eight-miRNA antibody predictive signature was associated with immune-related target mRNAs and pathways. These findings provide valuable insights into early blood biomarkers associated with rVSVΔG-ZEBOV-GP vaccine-induced IgG antibody responses. © 2023 The Author(s)
Authors & Co-Authors
Vianello, Eleonora
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Veen, Suzanne Q.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Santoro, Francesco
Italy, Siena
Università Degli Studi Di Siena
Agbajogu, Christopher
Sweden, Gothenburg
Göteborgs Universitet
Agnandji, Sélidji Todagbe M.
Unknown Affiliation
Ahmed, Rafi
Unknown Affiliation
Anderson, Jenna
Unknown Affiliation
Auderset, Floriane
Unknown Affiliation
Bejon, Philip A.
Unknown Affiliation
Borgianni, Luisa
Unknown Affiliation
Brosnahan, Jessica S.
Unknown Affiliation
Ciabattini, Annalisa
Unknown Affiliation
Engler, Olivier B.
Unknown Affiliation
Harandi, Ali M.
Sweden, Gothenburg
Göteborgs Universitet
Canada, Vancouver
The University of British Columbia
Heppner, Donald Gray
Unknown Affiliation
Gerlini, Alice
Unknown Affiliation
Huttner, Angela Csaki
Unknown Affiliation
Kremsner, Peter G.
Unknown Affiliation
Medaglini, Donata
Italy, Siena
Università Degli Studi Di Siena
Monath, Thomas P.C.
Unknown Affiliation
Ndung'u, Francis M.
Unknown Affiliation
Njuguna, Patricia
Unknown Affiliation
Ottenhoff, Tom H.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Pejoski, David
Unknown Affiliation
Page, Mark
Unknown Affiliation
Pozzi, Gianni
Unknown Affiliation
Siegrist, Claire Anne
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Dubey, Sheri A.
Unknown Affiliation
Eichberg, Michael J.
Unknown Affiliation
Gonzalez-Dias, Patrícia
Unknown Affiliation
Essone, Paulin Ndong
Unknown Affiliation
Kabwende, Lumeka
Unknown Affiliation
Kremsner, Peter Gottfried
Unknown Affiliation
Nakaya, Helder
Unknown Affiliation
Nakka, Sravya Sowdamini
Unknown Affiliation
Haks, Mariëlle C.
Unknown Affiliation
Rothenberger, Sylvia
Unknown Affiliation
Statistics
Citations: 1
Authors: 37
Affiliations: 7
Identifiers
Doi:
10.1016/j.isci.2023.108574
ISSN:
25890042
Research Areas
Infectious Diseases