Synthesis and antibacterial activity of new quinoline derivatives started from coumarin compounds

An efficient synthetic method for the preparation of quinoline derivatives started from coumarin compounds was described. Fused coumarin derivative 1 reacted with amm acetate to afford 3-methylene-quinoIine-2,4-dione 2. In the same way active methylene compounds as ethyl acetoacetate, ethyl cyanoacetate, acetyl acetone and malonitrile reacted with compound 1 and gave the corresponding quinolines derivatives 3-6. All the newly compounds were characterized by elemental analysis, IR and mass spectra.