Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adipokines as emerging depression biomarkers: A systematic review and meta-analysis
Journal of Psychiatric Research, Volume 59, Year 2014
Notification
URL copied to clipboard!
Description
Adiponectin, leptin and resistin may play a role in the pathophysiology of major depressive disorder (MDD). However, differences in peripheral levels of these hormones are inconsistent across diagnostic and intervention studies. Therefore, we performed meta-analyses of diagnostic studies (i.e., MDD subjects versus healthy controls) and intervention investigations (i.e., pre-vs. post-antidepressant treatment) in MDD. Adiponectin (N=1278; Hedge's g=-0.35; P=0.16) and leptin (N=893; Hedge's g=-0.018; P=0.93) did not differ across diagnostic studies. Meta-regression analyses revealed that gender and depression severity explained the heterogeneity observed in adiponectin diagnostic studies, while BMI and the difference in BMI between MDD individuals and controls explained the heterogeneity of leptin diagnostic studies. Subgroup analyses revealed that adiponectin peripheral levels were significantly lower in MDD participants compared to controls when assayed with RIA, but not ELISA. Leptin levels were significantly higher in individuals with mild/moderate depression versus controls. Resistin serum levels were lower in MDD individuals compared to healthy controls (N=298; Hedge's g=-0.25; P=0.03). Leptin serum levels did not change after antidepressant treatment. However, heterogeneity was significant and sample size was low (N=108); consequently meta-regression analysis could not be performed. Intervention meta-analyses could not be performed for adiponectin and resistin (i.e., few studies met inclusion criteria). In conclusion, this systematic review and meta-analysis underscored that relevant moderators/confounders (e.g., BMI, depression severity and type of assay) should be controlled for when considering the role of leptin and adiponectin as putative MDD diagnostic biomarkers. © 2014 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Carvalho, André F.
Brazil, Fortaleza
Universidade Federal do Ceará
Mcintyre, Roger S.
Canada, Toronto
University of Toronto
Köhler, Cristiano A.
Brazil, Natal
Universidade Federal do Rio Grande do Norte
Hyphantis, Thomas N.
Greece, Ioannina
University of Ioannina
Machado-Vieira, Rodrigo
United States, Bethesda
Instituto Nacional de la Salud Mental
Brazil, Sao Paulo
Universidade de São Paulo
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
The Florey
Australia, Melbourne
Orygen Youth Health
Statistics
Citations: 97
Authors: 6
Affiliations: 9
Identifiers
Doi:
10.1016/j.jpsychires.2014.08.002
ISSN:
00223956
Research Areas
Genetics And Genomics
Mental Health
Study Design
Randomised Control Trial
Study Approach
Quantitative
Systematic review