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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anemia is an independent predictor of mortality and immunologic progression of disease among women with HIV in Tanzania
Journal of Acquired Immune Deficiency Syndromes, Volume 40, No. 2, Year 2005
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Description
Objectives: To examine the association of anemia with mortality and disease progression among a cohort of women with HIV in Dar es Salaam, Tanzania. Methods: Time to all-cause death, AIDS-related death, and a 50% decrease in CD4 cell count among 1078 HIV-positive pregnant women enrolled in a clinical trial of vitamin supplementation from 1995-2003. Results: Adjusted models showed that anemia was associated with an increased risk of all-cause mortality (relative hazard [RH]: 2.06, 95% CI: 1.52 to 2.79 for moderate anemia and RH: 3.19, 95% CI: 2.23 to 4.56 for severe anemia) and AIDS-related mortality (RH: 2.21, 95% CI: 1.53 to 3.19 for moderate anemia and RH: 3.47, 95% CI: 2.25 to 5.33 for severe anemia), independent of CD4 cell count, World Health Organization clinical stage, age, pregnancy, vitamin supplementation, and body mass index. Anemia was also associated with a more rapid decline in CD4 counts, measured as time to a 50% drop in CD4 cell count from baseline. Erythrocyte characteristics suggestive of iron deficiency were also associated with all-cause and AIDS-related death and a 50% decline in CD4 cell count. Conclusions: Anemia is an independent predictor of mortality and disease progression in this cohort. Screening for anemia, coupled with prevention and treatment efforts, should be included in HIV care initiatives, particularly those that target women. Copyright © 2005 by Lippincott Williams & Wilkins.
Authors & Co-Authors
O'Brien, Megan
United States, Boston
Harvard T.h. Chan School of Public Health
Kupka, Roland
United States, Boston
Harvard T.h. Chan School of Public Health
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Saathoff, Elmar
United States, Boston
Harvard T.h. Chan School of Public Health
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 137
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1097/01.qai.0000166374.16222.a2
ISSN:
15254135
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Tanzania
Participants Gender
Female