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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Is nodule size an independent predictor of thyroid malignancy?
Surgery, Volume 144, No. 6, Year 2008
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Description
Background: A decision to proceed with thyroidectomy or to perform more extensive thyroidectomy based on nodule size is controversial. It was our hypothesis that larger nodules are more likely to be malignant, and, as a result, nodule size may be useful for guiding operative decision making. Methods: Data was obtained from a prospectively maintained database for patients with nodular thyroid disease evaluated from 1990 to 2007. Logistic regression analysis was performed to determine if there was a significant relationship between nodule size and malignancy based on final pathology. The relationship of nodule size and malignancy was further evaluated for specific diagnostic categories of fine needle aspiration biopsy (FNAB). Results: 1023 patients were evaluated for nodular thyroid disease and 676 underwent thyroidectomy. Mean size was 4.4 ± 2.4 cm for benign and 3.3 ± 2.2 cm for malignant nodules (P < .05). The size of benign and malignant nodules, as a function of FNAB, was not significantly different. Conclusion: Increasing nodule size was not predictive of thyroid malignancy suggesting that it should not be used in lieu of FNAB for therapeutic decision making. © 2008 Mosby, Inc. All rights reserved.
Authors & Co-Authors
MacHekano, Rhoderick Neri
United States, Cleveland
Case School of Medicine
Statistics
Citations: 130
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.1016/j.surg.2008.07.021
ISSN:
00396060
Research Areas
Cancer
Study Approach
Quantitative