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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Complete sequences of mitochondria genomes of aedes aegypti and culex quinquefasciatus and comparative analysis of mitochondrial dna fragments inserted in the nuclear genomes
Insect Biochemistry and Molecular Biology, Volume 41, No. 10, Year 2011
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Description
We present complete sequences of the mitochondrial genomes for two important mosquitoes, Aedes aegypti and Culex quinquefasciatus, that are major vectors of dengue virus and lymphatic filariasis, respectively. The A. aegypti mitochondrial genome is 16,655 bp in length and that of C. quinquefasciatus is 15,587 bp, yet both contain 13 protein coding genes, 22 transfer RNA (tRNA) genes, one 12S ribosomal RNA (rRNA) gene, one 16S rRNA gene and a control region (CR) in the same order. The difference in the genome size is due to the difference in the length of the control region. We also analyzed insertions of nuclear copies of mtDNA-like sequences (NUMTs) in a comparative manner between the two mosquitoes. The NUMT sequences occupy ∼0.008% of the A. aegypti genome and ∼0.001% of the C. quinquefasciatus genome. Several NUMTs were found localized in the introns of predicted protein coding genes in both genomes (32 genes in A. aegypti but only four in C. quinquefasciatus). None of these NUMT-containing genes had an ortholog between the two species or had paralogous copies within a genome that was also NUMT-containing. It was further observed that the NUMT-containing genes were relatively longer but had lower GC content compared to the NUMT-less paralogous copies. Moreover, stretches of homologies are present among the genic and non-genic NUMTs that may play important roles in genomic rearrangement of NUMTs in these genomes. Our study provides new insights on understanding the roles of nuclear mtDNA sequences in genome complexities of these mosquitoes. © 2011 Elsevier Ltd.
Authors & Co-Authors
Behura, Susanta K.
United States, Notre Dame
University of Notre Dame
Lobo, Neil Francis
United States, Notre Dame
University of Notre Dame
Haas, Brian J.
United States, Rockville
J. Craig Venter Institute
United States, Cambridge
Broad Institute
DeBruyn, Becky S.
United States, Notre Dame
University of Notre Dame
Lovin, Diane D.
United States, Notre Dame
University of Notre Dame
Shumway, Martin F.
United States, Rockville
J. Craig Venter Institute
United States, Bethesda
National Library of Medicine Nlm
Puiu, Daniela
United States, Rockville
J. Craig Venter Institute
United States, College Park
University of Maryland, College Park
Romero-Severson, Jeanne
United States, Notre Dame
University of Notre Dame
Nene, Vishvanath M.
United States, Rockville
J. Craig Venter Institute
Kenya, Nairobi
International Livestock Research Institute Nairobi
Severson, David W.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 97
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.ibmb.2011.05.006
ISSN:
09651748
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases