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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana
American Journal of Tropical Medicine and Hygiene, Volume 87, No. 6, Year 2012
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Description
In 2005, sulphadoxine-pyrimethamine (SP) became the drug of choice for intermittent preventive treatment of Plasmodium falciparum malaria in pregnancy (IPTp) in Ghana. Reports suggest the use of SP by others to treat uncomplicated malaria. Because of the increased use of SP, the prevalence of mutations in the genes, dihydrofolate reductase (dhfr), and dihydropteroate synthetase (dhps), linked to SP resistance in P. falciparum were determined. Blood samples from 945 children with uncomplicated malaria collected at nine sites from 2003 to 2010 were analyzed using polymerase chain reaction and restriction fragment length polymorphism. Prevalence of the dhfr triple and dhfr plus dhps quadruple mutations showed significant increase in trend from 2003 to 2010 (χ2 = 18.78, P < 0.001, χ2 = 15.11, P < 0.001, respectively). For dhps double mutant G437 + E540 the prevalence was low (1.12%) caused by the very low prevalence of E540. Our findings show the wide use of SP in Ghana and therefore its use for IPTp needs to be closely monitored. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Duah-Quashie, Nancy Odurowah
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Quashie, Neils Ben
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Abuaku, Benjamin Kwaku
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Sebeny, Peter J.
Ghana, Accra
University of Ghana
United States, Silver Spring
Naval Medical Research Center
Kronmann, Karl C.
Ghana, Accra
University of Ghana
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Koram, Kwadwo A.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Statistics
Citations: 34
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2012.12-0202
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Ghana