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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae
Journal of Biological Chemistry, Volume 288, No. 22, Year 2013
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Description
Anopheline mosquitoes are the only vectors of human malaria worldwide. It is now widely accepted that mosquito immune responses play a crucial role in restricting Plasmodium development within the vector; therefore, further dissection of the molecular mechanisms underlying these processes should inform new vector control strategies urgently needed to roll back the disease. Here, using genome-wide transcriptional profiling, bioinformatics, and functional gene analysis, we identify a new axis of mosquito resistance to monoclonal Plasmodium falciparum infections that includes the AP-1 transcription factor Fos and the transglutaminase 2 (TGase2), a cross-linking enzyme with known roles in wound responses. We demonstrate that Fos regulates induction of TGase2 expression after wounding but does not affect expression of the components of the well characterized complement-like system. Silencing of Fos or of TGase2 aborts the wounding-induced mosquito killing of P. falciparum. These results reveal multiple signaling pathways that are required for efficient Plasmodium killing in Anopheles gambiae. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_288_22_16145__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-4.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-5.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-6.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-7.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-8.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-9.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-10.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3668770/bin/supp_M112.443267_jbc.M112.443267-11.docx
Authors & Co-Authors
Nsango, Sandrine Eveline
France, Strasbourg
Université de Strasbourg
Cameroon, Yaounde
Laboratoire de Recherche Sur le Paludisme Yaounde
France, Montpellier
Ird Centre de Montpellier
Pompon, Julien Francis
France, Strasbourg
Université de Strasbourg
Xie, Ting
France, Strasbourg
Université de Strasbourg
Rademacher, Annika
France, Strasbourg
Université de Strasbourg
Fraiture, Malou
France, Strasbourg
Université de Strasbourg
Thoma, Martine
France, Strasbourg
Université de Strasbourg
Luxembourg
Laboratories Reunis Junglinster
Awono-Ambéné, Parfait Herman
Cameroon, Yaounde
Laboratoire de Recherche Sur le Paludisme Yaounde
Moyou, Roger Somo
Cameroon, Yaounde
Université de Yaoundé I
Morlais, Isabelle
Cameroon, Yaounde
Laboratoire de Recherche Sur le Paludisme Yaounde
Cameroon, Yaounde
Université de Yaoundé I
Levashina, Elena A.
France, Strasbourg
Université de Strasbourg
Germany, Berlin
Max Planck Institute for Infection Biology
Statistics
Citations: 21
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1074/jbc.M112.443267
ISSN:
00219258
e-ISSN:
1083351X
Research Areas
Genetics And Genomics
Infectious Diseases