Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Science, Volume 364, No. 6436, Year 2019
Notification
URL copied to clipboard!
Description
Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4-power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy. © 2017 The Authors.
Authors & Co-Authors
Bigley, Rachel B.
United States, San Francisco
University of California, San Francisco
Smith, Megan
United States, San Francisco
Calico Llc
Reeder, Deeann M.
United States, Lewisburg
Bucknell University
Maden, Malcolm
United States, Gainesville
University of Florida
Buffenstein, Rochelle B.
United States, San Francisco
Calico Llc
Statistics
Citations: 215
Authors: 5
Affiliations: 11
Identifiers
Doi:
10.1126/science.aar2038
ISSN:
00368075
Research Areas
Maternal And Child Health
Noncommunicable Diseases